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TRPA1-IN-2

CAS No. 2415206-22-1

TRPA1-IN-2( —— )

Catalog No. M36925 CAS No. 2415206-22-1

TRPA1-IN-2 is a potent and orally active TRPA1 inhibitor with an IC50 value of 0.04 μM.TRPA1-IN-2 has anti-inflammatory activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    TRPA1-IN-2
  • Note
    Research use only, not for human use.
  • Brief Description
    TRPA1-IN-2 is a potent and orally active TRPA1 inhibitor with an IC50 value of 0.04 μM.TRPA1-IN-2 has anti-inflammatory activity.
  • Description
    TRPA1-IN-2 (compound 1) is a potent and orally active TRPA1 inhibitor with an IC50 value of 0.04 μM. TRPA1-IN-2 shows anti-inflammation activity.
  • In Vitro
    ——
  • In Vivo
    Animal Model:16-18 g, female BABL/c mice Dosage:90 mg/kg Administration:I.p.; for 7 days Result:Reduced the total number of white blood cells and eosinophils in BALF.Animal Model:160-180 g, SD male rats (asthmatic rats)Dosage:30 mg/kg Administration:I.p.; for 7 days Result:Significantly Sexually reduced lung inflammation area and airway inflammation score in asthmatic rats.
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    TRP/TRPV Channel
  • Recptor
    TRP/TRPV Channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2415206-22-1
  • Formula Weight
    442.48
  • Molecular Formula
    C24H25F3N4O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (226.00 mM; Ultrasonic )
  • SMILES
    C(=O)(C1(NC2=CC=C(C#N)C=C2)CCCC1)N3CCN(CC3)C4=CC=C(C(F)(F)F)C=C4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. YunFeng Cheng, et al. Heteroaromatic acetamide derivative, and preparation and use thereof. WO2020244460A1.
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