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PF-00562271
CAS No. 939791-38-5
PF-00562271 ( —— )
Catalog No. M16725 CAS No. 939791-38-5
PF-00562271 is the benzenesulfonate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM.
Purity : >98%(HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 67 | In Stock |
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| 5MG | 108 | In Stock |
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| 10MG | 135 | In Stock |
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| 25MG | 224 | In Stock |
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| 50MG | 332 | In Stock |
|
| 100MG | 494 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NamePF-00562271
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NoteResearch use only, not for human use.
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Brief DescriptionPF-00562271 is the benzenesulfonate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM.
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DescriptionPF-00562271 is the benzenesulfonate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Phase 1.
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Synonyms——
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK1/CyclinB; CDK2/CyclinE; CDK3/CyclinE; FAK; PYK2
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Research AreaCancer
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IndicationSolid Tumors
Chemical Information
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CAS Number939791-38-5
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Formula Weight665.66
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Molecular FormulaC21H20F3N7O3S.C6H6O3S
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Purity>98%(HPLC)
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SolubilityDMSO:14 mg/mL warmed (21.03 mM); Ethanol:<1 mg/mL (<1 mM); Water:<1 mg/mL (<1 mM)
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SMILESOS(=O)(=O)C1=CC=CC=C1.CN(C1=C(CNC2=C(C=NC(NC3=CC=C4NC(=O)CC4=C3)=N2)C(F)(F)F)C=CC=N1)S(C)(=O)=O |c:6,8,12,18,31,33,40,42,t:4,16,22,24|
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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CCT251545
CCT251545 is a potent, orally bioavailable inhibitor of Wnt signaling with IC50 of 5 nM, also is a potent and selective chemical probe for CDK8 and CDK19 with >100-fold selectivity over 291 other kinases; potently inhibits reporter-based readouts of basal WNT pathway activity in LS174T and SW480 cells in the absence of WNT ligand with IC50 of 23 and 190 nM, respectively.
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AT-7519 hydrochlorid...
A potent CDK2 inhibitor with IC50 of 47 nM; also inhibits CDK1/4/5 with IC50 of 190/67/18 nM and shows selectivity over some kinases (Aurora A, IR kinase, MEK, PDK1, c-Abl, IC50>10 uM).
