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PD173074

CAS No. 219580-11-7

PD173074( PD173074 | PD 173074 | PD-173074 )

Catalog No. M13497 CAS No. 219580-11-7

PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM in cell-free assays, ~1000-fold selective for FGFR1 than PDGFR and c-Src.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PD173074
  • Note
    Research use only, not for human use.
  • Brief Description
    PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM in cell-free assays, ~1000-fold selective for FGFR1 than PDGFR and c-Src.
  • Description
    PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM in cell-free assays, ~1000-fold selective for FGFR1 than PDGFR and c-Src.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    PD173074 | PD 173074 | PD-173074
  • Pathway
    Angiogenesis
  • Target
    EGFR
  • Recptor
    EGFR| FGFR1| Insulin Receptor| c-Src| VEGFR2
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    219580-11-7
  • Formula Weight
    523.67
  • Molecular Formula
    C28H41N7O3
  • Purity
    >98% (HPLC)
  • Solubility
    Ethanol: 100 mg/mL (190.95 mM); DMSO: 100 mg/mL (190.95 mM)
  • SMILES
    O=C(NC1=NC2=NC(NCCCCN(CC)CC)=NC=C2C=C1C3=CC(OC)=CC(OC)=C3)NC(C)(C)C
  • Chemical Name
    1-(tert-butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Mohammadi M, et al. EMBO J, 1998, 17(20), 5896-5904.
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