PD173074( PD173074 | PD 173074 | PD-173074 )

Catalog No. M13497 CAS No. 219580-11-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

PD173074
Note

Research use only, not for human use.
Brief Description

PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM in cell-free assays, ~1000-fold selective for FGFR1 than PDGFR and c-Src.
Description

PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM in cell-free assays, ~1000-fold selective for FGFR1 than PDGFR and c-Src.
In Vitro

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In Vivo

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Synonyms

PD173074 | PD 173074 | PD-173074
Pathway

Angiogenesis
Target

EGFR
Recptor

EGFR| FGFR1| Insulin Receptor| c-Src| VEGFR2
Research Area

Cancer
Indication

——

CAS Number

219580-11-7
Formula Weight

523.67
Molecular Formula

C28H41N7O3
Purity

>98% (HPLC)
Solubility

Ethanol: 100 mg/mL (190.95 mM); DMSO: 100 mg/mL (190.95 mM)
SMILES

O=C(NC1=NC2=NC(NCCCCN(CC)CC)=NC=C2C=C1C3=CC(OC)=CC(OC)=C3)NC(C)(C)C
Chemical Name

1-(tert-butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea

1.Mohammadi M, et al. EMBO J, 1998, 17(20), 5896-5904.

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