PD173074

CAS No. 219580-11-7

PD173074 ( PD173074; PD 173074; PD-173074 )

Catalog No. M13497 CAS No. 219580-11-7

PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM in cell-free assays, ~1000-fold selective for FGFR1 than PDGFR and c-Src.

Purity : >98%(HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 32 In Stock
10MG 47 In Stock
25MG 82 In Stock
50MG 129 In Stock
100MG 210 In Stock
200MG 372 In Stock
500MG 620 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    PD173074
  • Note
    Research use only, not for human use.
  • Brief Description
    PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM in cell-free assays, ~1000-fold selective for FGFR1 than PDGFR and c-Src.
  • Description
    PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM in cell-free assays, ~1000-fold selective for FGFR1 than PDGFR and c-Src.
  • Synonyms
    PD173074; PD 173074; PD-173074
  • Pathway
    Angiogenesis
  • Target
    EGFR
  • Recptor
    EGFR; FGFR1; Insulin Receptor; c-Src; VEGFR2
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    219580-11-7
  • Formula Weight
    523.67
  • Molecular Formula
    C28H41N7O3
  • Purity
    >98%(HPLC)
  • Solubility
    Ethanol: 100 mg/mL (190.95 mM); DMSO: 100 mg/mL (190.95 mM)
  • SMILES
    O=C(NC1=NC2=NC(NCCCCN(CC)CC)=NC=C2C=C1C3=CC(OC)=CC(OC)=C3)NC(C)(C)C
  • Chemical Name
    1-(tert-butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Mohammadi M, et al. EMBO J, 1998, 17(20), 5896-5904.
molnova catalog
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