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AZD-9291
CAS No. 1421373-65-0
AZD-9291 ( Osimertinib;Mereletinib;AZD9291;AZD 9291 )
Catalog No. M11762 CAS No. 1421373-65-0
A potent, selective, third-generation irreversible inhibitor of mutant EGFR with IC50s of 1/12/5 nM for L858R-T790M/L858R/L861Q respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 31 | In Stock |
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| 5MG | 43 | In Stock |
|
| 10MG | 52 | In Stock |
|
| 25MG | 63 | In Stock |
|
| 100MG | 88 | In Stock |
|
| 200MG | 105 | In Stock |
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| 1G | 141 | In Stock |
|
Biological Information
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Product NameAZD-9291
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, third-generation irreversible inhibitor of mutant EGFR with IC50s of 1/12/5 nM for L858R-T790M/L858R/L861Q respectively.
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DescriptionA potent, selective, third-generation irreversible inhibitor of mutant EGFR with IC50s of 1/12/5 nM for L858R-T790M/L858R/L861Q respectively; weak activity against wt EGFR (IC50=184 nM); inhibits signaling pathways and cellular growth in both EGFRm(+) and EGFRm(+)/T790M(+) mutant cell lines in vitro; exhibits tumor regression in EGFR-mutant tumor xenograft and transgenic models; orally active.Lung Cancer Approved
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SynonymsOsimertinib;Mereletinib;AZD9291;AZD 9291
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PathwayAngiogenesis
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TargetEGFR
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RecptorEGFR(Exon19deletion);EGFR(L858R/T790M)
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Research AreaCancer
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IndicationLung Cancer
Chemical Information
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CAS Number1421373-65-0
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Formula Weight499.61
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Molecular FormulaC28H33N7O2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 30 mg/mL
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SMILESCOC1=C(NC2=NC=CC(=N2)C2=CN(C)C3=CC=CC=C23)C=C(NC(=O)C=C)C(=C1)N(C)CCN(C)C
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Chemical Name2-Propenamide, N-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Finlay MR, et al. J Med Chem. 2014 Oct 23;57(20):8249-67.
2. Cross DA, et al. Cancer Discov. 2014 Sep;4(9):1046-61.
3. Eberlein CA, et al. Cancer Res. 2015 Jun 15;75(12):2489-500.
2. Cross DA, et al. Cancer Discov. 2014 Sep;4(9):1046-61.
3. Eberlein CA, et al. Cancer Res. 2015 Jun 15;75(12):2489-500.
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