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PD158780
CAS No. 171179-06-9
PD158780 ( —— )
Catalog No. M20133 CAS No. 171179-06-9
PD 158780 reversibly inhibits auto and transphosphorylation of all four members of the ErbB receptor superfamily: EGFR ErbB2 ErbB3 and ErbB4 (IC50s: 8μM 49 nM 52 nM and 52 nM in cell assay).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 69 | In Stock |
|
| 10MG | 110 | In Stock |
|
| 25MG | 205 | In Stock |
|
| 50MG | 357 | In Stock |
|
| 100MG | 524 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePD158780
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NoteResearch use only not for human use.
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Brief DescriptionPD 158780 reversibly inhibits auto and transphosphorylation of all four members of the ErbB receptor superfamily: EGFR ErbB2 ErbB3 and ErbB4 (IC50s: 8μM 49 nM 52 nM and 52 nM in cell assay).
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DescriptionPD 158780 reversibly inhibits auto and transphosphorylation of all four members of the ErbB receptor superfamily: EGFR ErbB2 ErbB3 and ErbB4 (IC50s: 8μM 49 nM 52 nM and 52 nM in cell assay).
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Synonyms——
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PathwayAngiogenesis
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TargetEGFR
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RecptorEGFR; ErbB2; ErbB3; ErbB4
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Research Area——
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Indication——
Chemical Information
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CAS Number171179-06-9
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Formula Weight330.19
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Molecular FormulaC14H12BrN5
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Purity>98% (HPLC)
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SolubilityDMSO: 30 mg/mL (90.86 mM);Ethanol: 8 mg/mL (24.23 mM)
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SMILESCNc1cc2c(Nc3cccc(Br)c3)ncnc2cn1
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Chemical Name4-N-(3-bromophenyl)-6-N-methylpyrido[34-d]pyrimidine-46-diamine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Fry DW et al. Biochemical and antiproliferative properties of 4-[ar(alk)ylamino]pyridopyrimidines a new chemical class of potent and specific epidermal growth factor receptor tyrosine kinase inhibitor. Biochem Pharmacol. 1997 Oct 15;54(8):877-87.
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