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RO 46-8443
CAS No. 175556-12-4
RO 46-8443( RO 46-8443 | RO46-8443 | RO-46-8443 | RO 468443 )
Catalog No. M17374 CAS No. 175556-12-4
RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibitory potency and functional inhibition.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 46 | In Stock |
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| 5MG | 76 | In Stock |
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| 10MG | 122 | In Stock |
|
| 25MG | 250 | In Stock |
|
| 50MG | 346 | In Stock |
|
| 100MG | 511 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1088 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameRO 46-8443
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NoteResearch use only, not for human use.
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Brief DescriptionRO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibitory potency and functional inhibition.
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DescriptionRO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibitory potency and functional inhibition. The observed parallel rightward shift of concentration-response curves with different antagonist concentrations is consistent with a competitive binding mode. Since R0 46-8443 selectively inhibits ETB receptor mediated responses, it is a valuable tool for clarifying the role of ETB receptors in pathology.
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In Vitro——
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In Vivo——
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SynonymsRO 46-8443 | RO46-8443 | RO-46-8443 | RO 468443
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PathwayAngiogenesis
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TargetEGFR
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RecptorET-B
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Research Area——
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Indication——
Chemical Information
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CAS Number175556-12-4
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Formula Weight609.69
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Molecular FormulaC31H35N3O8S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (410.04 mM)
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SMILESc1(ccc(cc1)C(C)(C)C)S(=O)(=O)Nc1nc(nc(c1Oc1c(cccc1)OC)OC[C@@H](CO)O)c1ccc(cc1)OC
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Chemical Name4-(tert-butyl)-N-(6-(2,3-dihydroxypropoxy)-5-(2-methoxyphenoxy)-2-(4-methoxyphenyl)pyrimidin-4-yl)benzenesulfonamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Guimar?es CL, Trentin PG, Rae GA. Endothelin ET(B) receptor-mediated mechanisms involved in oleic acid-induced acute lung injury in mice. Clin Sci (Lond). 2002 Aug;103 Suppl 48:340S-344S.
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