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RO 46-8443
CAS No. 175556-12-4
RO 46-8443( RO 46-8443 | RO46-8443 | RO-46-8443 | RO 468443 )
Catalog No. M17374 CAS No. 175556-12-4
RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibitory potency and functional inhibition.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 46 | In Stock |
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| 5MG | 76 | In Stock |
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| 10MG | 122 | In Stock |
|
| 25MG | 250 | In Stock |
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| 50MG | 346 | In Stock |
|
| 100MG | 511 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | 1088 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameRO 46-8443
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NoteResearch use only, not for human use.
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Brief DescriptionRO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibitory potency and functional inhibition.
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DescriptionRO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibitory potency and functional inhibition. The observed parallel rightward shift of concentration-response curves with different antagonist concentrations is consistent with a competitive binding mode. Since R0 46-8443 selectively inhibits ETB receptor mediated responses, it is a valuable tool for clarifying the role of ETB receptors in pathology.
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In Vitro——
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In Vivo——
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SynonymsRO 46-8443 | RO46-8443 | RO-46-8443 | RO 468443
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PathwayAngiogenesis
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TargetEGFR
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RecptorET-B
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Research Area——
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Indication——
Chemical Information
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CAS Number175556-12-4
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Formula Weight609.69
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Molecular FormulaC31H35N3O8S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (410.04 mM)
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SMILESc1(ccc(cc1)C(C)(C)C)S(=O)(=O)Nc1nc(nc(c1Oc1c(cccc1)OC)OC[C@@H](CO)O)c1ccc(cc1)OC
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Chemical Name4-(tert-butyl)-N-(6-(2,3-dihydroxypropoxy)-5-(2-methoxyphenoxy)-2-(4-methoxyphenyl)pyrimidin-4-yl)benzenesulfonamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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PF-06459988
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Poziotinib hydrochlo...
Poziotinib hydrochloride irreversibly inhibits EGFR (HER1 or ErbB1), including EGFR mutants, HER2, and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors.?It is an orally bioavailable, quinazoline-based pan epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity.?
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Theliatinib
Theliatinib a potent and highly selective EGFR inhibitor with anti-tumor activity. Ki of 0.05 nM for wild type EGFR and IC50s of 3 and 22 nM for EGFR and EGFR T790M/L858R mutant respectively.
