Cart
sales@molnova.com
PD-321852
CAS No. 622856-21-7
PD-321852( PD 321852 | PD321852 )
Catalog No. M15356 CAS No. 622856-21-7
A potent, reasonably selective Chk1 inhibitor with cell IC50 of 5 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1233 | Get Quote |
|
| 50MG | 2502 | Get Quote |
|
| 100MG | 3330 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NamePD-321852
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, reasonably selective Chk1 inhibitor with cell IC50 of 5 nM.
-
DescriptionA potent, reasonably selective Chk1 inhibitor with cell IC50 of 5 nM; potentiates gemcitabine-induced clonogenic death in a panel of pancreatic cancer cell lines; inhibits gemcitabine-induced Rad51 focus formation, and depletes RAD51 proteins in pancreatic cancer cells.
-
In Vitro——
-
In Vivo——
-
SynonymsPD 321852 | PD321852
-
PathwayAngiogenesis
-
TargetChk
-
RecptorChk
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number622856-21-7
-
Formula Weight468.33
-
Molecular FormulaC24H19Cl2N3O3
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C1NC(C2=C1C3=C(C=C2C4=C(Cl)C=CC=C4Cl)N(CCCNC)C5=C3C=C(O)C=C5)=O
-
Chemical Name4-(2,6-dichlorophenyl)-9-hydroxy-6-(3-(methylamino)propyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Parsels LA, et al. Mol Cancer Ther. 2009 Jan;8(1):45-54.
molnova catalog
related products
-
PV-1115
A potent and highly selective Chk2 inhibitor with IC50 of 0.14 nM; displays greater than 100 uM for Chk1 in vitro.
-
PF-00477736
PF-00477736 (PF-477736) is a potent, selective, ATP-competitive inhibitor of Chk1 with Ki of 0.49 nM, also inhibits Chk2 (Ki=47 nM) and poorly inhibits CDK1 activity (Ki=9.9 uM).
-
4-Demethyldeoxypodop...
4-Demethyldeoxypodophyllotoxin, an aryl tetrahydronaphthalenyl lignan analog from the roots of Podophyllum peltatum, has anticancer activity and modulates the Chk-2 signaling pathway in MCF-7 breast cancer cells.
