PD-118057

Research use only, not for human use.

A potent, selective hERG potassium channel (Kv11.1) activator that increases peak tail hERG current of 111.1% at 10 uM in HEK293 cells.

A potent, selective hERG potassium channel (Kv11.1) activator that increases peak tail hERG current of 111.1% at 10 uM in HEK293 cells; does not ot affect the voltage dependence and kinetics of gating parameters, and open conformation of the channel, also shows no major effect on I(Na), I(Ca,L), I(K1), and I(Ks); shortens the action potential duration and QT interval in arterially perfused rabbit ventricular wedge preparation, prevents action potential duration and QT prolongation caused by dofetilide at 3 uM.Heart Arrhythmia Discontinued

PD 118057;PD118057

Cell Cycle/DNA Damage

Potassium Channel

Potassium Channel

Cardiovascular Disease

Heart Arrhythmia

313674-97-4

386.27

C21H17Cl2NO2

>98% (HPLC)

——

O=C(O)C1=CC=CC=C1NC2=CC=C(CCC3=CC=C(Cl)C(Cl)=C3)C=C2

2-{4-[2-(3,4-dichloro-phenyl)-ethyl]-phenylamino}-benzoic acid

(-20℃)

With Ice Pack

≥ 2 years