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Home - Products - Cell Cycle/DNA Damage - Potassium Channel - PD-118057

PD-118057

CAS No. 313674-97-4

PD-118057 ( PD 118057;PD118057 )

Catalog No. M14010 CAS No. 313674-97-4

A potent, selective hERG potassium channel (Kv11.1) activator that increases peak tail hERG current of 111.1% at 10 uM in HEK293 cells.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    PD-118057
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective hERG potassium channel (Kv11.1) activator that increases peak tail hERG current of 111.1% at 10 uM in HEK293 cells.
  • Description
    A potent, selective hERG potassium channel (Kv11.1) activator that increases peak tail hERG current of 111.1% at 10 uM in HEK293 cells; does not ot affect the voltage dependence and kinetics of gating parameters, and open conformation of the channel, also shows no major effect on I(Na), I(Ca,L), I(K1), and I(Ks); shortens the action potential duration and QT interval in arterially perfused rabbit ventricular wedge preparation, prevents action potential duration and QT prolongation caused by dofetilide at 3 uM.Heart Arrhythmia Discontinued
  • Synonyms
    PD 118057;PD118057
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Potassium Channel
  • Recptor
    Potassium Channel
  • Research Area
    Cardiovascular Disease
  • Indication
    Heart Arrhythmia

Chemical Information

  • CAS Number
    313674-97-4
  • Formula Weight
    386.27
  • Molecular Formula
    C21H17Cl2NO2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(O)C1=CC=CC=C1NC2=CC=C(CCC3=CC=C(Cl)C(Cl)=C3)C=C2
  • Chemical Name
    2-{4-[2-(3,4-dichloro-phenyl)-ethyl]-phenylamino}-benzoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zhou J, et al. Mol Pharmacol. 2005 Sep;68(3):876-84. Epub 2005 Jun 23.
2. Patel C, et al. Heart Rhythm. 2008 Apr;5(4):585-90.
3. Perry M, et al. Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):20075-80.
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