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BMS-204352
CAS No. 187523-35-9
BMS-204352 ( BMS 204352;Maxipost;BMS204352 )
Catalog No. M12907 CAS No. 187523-35-9
A potent and effective calcium-sensitive opener of maxi-K potassium channels (maxi-K) with EC50 of 392 nM at -48.4 mV in HEK293 isolated outside-out membrane patches.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 115 | Get Quote |
|
| 10MG | 170 | Get Quote |
|
| 25MG | 357 | Get Quote |
|
| 50MG | 533 | Get Quote |
|
| 100MG | 761 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameBMS-204352
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and effective calcium-sensitive opener of maxi-K potassium channels (maxi-K) with EC50 of 392 nM at -48.4 mV in HEK293 isolated outside-out membrane patches.
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DescriptionA potent and effective calcium-sensitive opener of maxi-K potassium channels (maxi-K) with EC50 of 392 nM at -48.4 mV in HEK293 isolated outside-out membrane patches; a potent and effective opener of two important subtypes of neuronal potassium channels, K(Ca) channels and KCNQ channels, strongly activates the voltage-gated K+ channel KCNQ5 with EC50 of 2.4 uM; shows significant levels of cortical neuroprotection in rat models of permanent large-vessel stroke.Stroke Phase 3 Discontinued
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SynonymsBMS 204352;Maxipost;BMS204352
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PathwayCell Cycle/DNA Damage
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TargetPotassium Channel
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RecptorPotassium Channel
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Research AreaNeurological Disease
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IndicationStroke
Chemical Information
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CAS Number187523-35-9
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Formula Weight359.70
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Molecular FormulaC16H10ClF4NO2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1NC2=C(C=CC(C(F)(F)F)=C2)[C@@]1(C3=CC(Cl)=CC=C3OC)F
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Chemical Name(3S)-(+)-(5-Chloro-2-methoxyphenyl)-1,3-dihydro-3-fluoro-6-(trifluoromethyl)-2H-indole-2-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gribkoff VK, et al. Nat Med. 2001 Apr;7(4):471-7.
2. Schrder RL, et al. Neuropharmacology. 2001 Jun;40(7):888-98.
3. Dupuis DS, et al. Eur J Pharmacol. 2002 Feb 22;437(3):129-37.
4. Hewawasam P, et al. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1023-6.
2. Schrder RL, et al. Neuropharmacology. 2001 Jun;40(7):888-98.
3. Dupuis DS, et al. Eur J Pharmacol. 2002 Feb 22;437(3):129-37.
4. Hewawasam P, et al. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1023-6.
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