Cart
sales@molnova.com
PC945
CAS No. 1931946-73-4
PC945 ( PC 945 )
Catalog No. M13027 CAS No. 1931946-73-4
PC945 is a novel broad spectrum antifungal agent that potently inhibits Aspergillus fumigatus sterol 14α-demethylase (CYP51A and CYP51B) with IC50 of 0.23 and 0.22 uM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 427 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NamePC945
-
NoteResearch use only, not for human use.
-
Brief DescriptionPC945 is a novel broad spectrum antifungal agent that potently inhibits Aspergillus fumigatus sterol 14α-demethylase (CYP51A and CYP51B) with IC50 of 0.23 and 0.22 uM, respectively.
-
DescriptionPC945 is a novel broad spectrum antifungal agent that potently inhibits Aspergillus fumigatus sterol 14α-demethylase (CYP51A and CYP51B) with IC50 of 0.23 and 0.22 uM, respectively; shows MIC values 0.032 to >8 ug/ml against 96 clinically isolated A. fumigatus strains, demonstrates activity against itraconazole-susceptible and -resistant A. fumigatus growth with IC50 of 0.0012 to 0.034 ug/ml; PC945 is a broad spectrum of pathogenic fungi with MIC 0.0078 to 2 ug/ml, and exhibits activity in vivo.Fungal Infection Phase 1 Clinical
-
SynonymsPC 945
-
PathwayMicrobiology/Virology
-
TargetFungal
-
RecptorFungal
-
Research AreaInfection
-
IndicationFungal Infection
Chemical Information
-
CAS Number1931946-73-4
-
Formula Weight682.75
-
Molecular FormulaC38H37F3N6O3
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES——
-
Chemical Name4-[4-(4-{[(3R,5R)-5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy}-3-methylphenyl)piperazin-1-yl]-N-(4-fluorophenyl)benzamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Colley T, et al. Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02280-16.
2. Kimura G, et al. Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00124-17.
2. Kimura G, et al. Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00124-17.
molnova catalog
related products
-
PC945
PC945 is a novel broad spectrum antifungal agent that potently inhibits Aspergillus fumigatus sterol 14α-demethylase (CYP51A and CYP51B) with IC50 of 0.23 and 0.22 uM, respectively.
-
Pneumocandin B0
A strong antifungal and inhibits the synthesis of 3-beta-D-glucan synthase.
-
Clotrimazole
An antifungal agent that works by altering the permeability of the fungal cell wall.
