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AN-2690
CAS No. 174671-46-6
AN-2690( Tavaborole | AN2690 | AN 2690 )
Catalog No. M12647 CAS No. 174671-46-6
An antifungal compound that inhibits cytoplasmic leucyl-tRNA synthetase for the potential treatment of nnychomycosis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 38 | In Stock |
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| 25MG | 49 | In Stock |
|
| 50MG | 52 | In Stock |
|
| 100MG | 59 | In Stock |
|
| 200MG | 75 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAN-2690
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NoteResearch use only, not for human use.
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Brief DescriptionAn antifungal compound that inhibits cytoplasmic leucyl-tRNA synthetase for the potential treatment of nnychomycosis.
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DescriptionAn antifungal compound that inhibits cytoplasmic leucyl-tRNA synthetase for the potential treatment of nnychomycosis; inhibits T. rubrum, T. mentagrophytes, C. albicans, C. neoformans with MIC50s of 0.25-1ug/mL.(In Vitro):Tavaborole (AN-2690) shows an 8-fold increase in activity against C. neoformans, and an 8-fold increase in activity against A. fumigatus. Tavaborole (AN-2690) obviously inhibit the cells expressing GlLeuRS-D444A, but has no effect on the cells expressing GlLeuRS and GlLeuRS-D444E.
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In VitroTavaborole (AN-2690) shows an 8-fold increase in activity against C. neoformans, and an 8-fold increase in activity against A. fumigatus. Tavaborole (AN-2690) obviously inhibit the cells expressing GlLeuRS-D444A, but has no effect on the cells expressing GlLeuRS and GlLeuRS-D444E.
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In Vivo——
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SynonymsTavaborole | AN2690 | AN 2690
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PathwayMicrobiology/Virology
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TargetFungal
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RecptorAntifungle
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Research AreaInfection
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Indication——
Chemical Information
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CAS Number174671-46-6
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Formula Weight151.9307
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Molecular FormulaC7H6BFO2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESOB1OCC2=CC(F)=CC=C12
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Chemical Name2,1-Benzoxaborole, 5-fluoro-1,3-dihydro-1-hydroxy-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Baker SJ, et al. J Med Chem. 2006 Jul 27;49(15):4447-50.
2. Rock FL, et al. Science. 2007 Jun 22;316(5832):1759-61.
3. Sarkar J, et al. FEBS Lett. 2011 Oct 3;585(19):2986-91.
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