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VT-1161
CAS No. 1340593-59-0
VT-1161 ( VT1161 )
Catalog No. M11365 CAS No. 1340593-59-0
VT-1161 is a potent, highly-selective, and oral fungal CYP51 inhibitor with Kd of ≤ 39 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 260 | Get Quote |
|
| 10MG | 410 | Get Quote |
|
| 25MG | 740 | Get Quote |
|
| 50MG | 1233 | Get Quote |
|
| 100MG | 1647 | Get Quote |
|
| 200MG | 2232 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameVT-1161
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NoteResearch use only, not for human use.
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Brief DescriptionVT-1161 is a potent, highly-selective, and oral fungal CYP51 inhibitor with Kd of ≤ 39 nM.
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DescriptionVT-1161 is a potent, highly-selective, and oral fungal CYP51 inhibitor with Kd of ≤ 39 nM; demonstrates >2,000-fold selectivit over human CYP51, weakly inhibits human CYP2C9, CYP2C19, and CYP3A4; exhibits excellent potency against key yeast and dermatophyte strains.Fungal Infection Phase 2 Clinical
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SynonymsVT1161
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PathwayMicrobiology/Virology
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TargetFungal
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RecptorFungal
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Research AreaInfection
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IndicationFungal Infection
Chemical Information
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CAS Number1340593-59-0
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Formula Weight527.40
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Molecular FormulaC23H16F7N5O2
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Purity>98% (HPLC)
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Solubility——
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SMILESFC(F)(COC1=CC=C(C=C1)C2=CN=C(C=C2)C(F)(F)[C@@](O)(C3=CC=C(C=C3F)F)CN4N=NN=C4)F
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Chemical Name(R)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-(4-(2,2,2-trifluoroethoxy)phenyl)pyridin-2-yl)propan-2-ol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hoekstra WJ, et al. Bioorg Med Chem Lett. 2014 Aug 1;24(15):3455-8.
2. Warrilow AG, et al. Antimicrob Agents Chemother. 2014 Dec;58(12):7121-7.
3. Garvey EP, et al. Antimicrob Agents Chemother. 2015 Sep;59(9):5567-73.
2. Warrilow AG, et al. Antimicrob Agents Chemother. 2014 Dec;58(12):7121-7.
3. Garvey EP, et al. Antimicrob Agents Chemother. 2015 Sep;59(9):5567-73.
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