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PAT-048
CAS No. 1359983-15-5
PAT-048 ( PAT 048;PAT048 )
Catalog No. M11477 CAS No. 1359983-15-5
PAT-048 (PAT048) is apotent, selective, noncompetitive autotaxin inhibitor with IC50 of 1.1 nM against the lysoPLD activity of human ATX.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 963 | Get Quote |
|
| 50MG | 1962 | Get Quote |
|
| 100MG | 2520 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NamePAT-048
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NoteResearch use only, not for human use.
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Brief DescriptionPAT-048 (PAT048) is apotent, selective, noncompetitive autotaxin inhibitor with IC50 of 1.1 nM against the lysoPLD activity of human ATX.
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DescriptionPAT-048 (PAT048) is apotent, selective, noncompetitive autotaxin inhibitor with IC50 of 1.1 nM against the lysoPLD activity of human ATX; exhibits good potency for inhibition of lysoPLD activity with IC50 of 8.9 nM and 22 nM in human blood and mouse plasma, respectively; decreases ATX activity systemically and in the lung, without effect on pulmonary LPA or fibrosis in bleomycin-challenged mice.
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SynonymsPAT 048;PAT048
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PathwayWnt/Notch/Hedgehog
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TargetAutotaxin
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RecptorAutotaxin
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Research Area——
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Indication——
Chemical Information
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CAS Number1359983-15-5
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Formula Weight461.91
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Molecular FormulaC22H18ClF2N3O2S
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Purity>98% (HPLC)
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Solubility——
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SMILESCCCN1N=CC(N2C(C(F)=C(Cl)C=C3)=C3C(SC4=CC=CC(C(O)=O)=C4F)=C2C)=C1
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Chemical Name3-((6-chloro-7-fluoro-2-methyl-1-(1-propyl-1H-pyrazol-4-yl)-1H-indol-3-yl)thio)-2-fluorobenzoic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Black KE, et al. FASEB J. 2016 Jun;30(6):2435-50.
2. Castelino FV, et al. Arthritis Rheumatol. 2016 Dec;68(12):2964-2974.
3. Bain G, et al. J Pharmacol Exp Ther. 2017 Jan;360(1):1-13.
2. Castelino FV, et al. Arthritis Rheumatol. 2016 Dec;68(12):2964-2974.
3. Bain G, et al. J Pharmacol Exp Ther. 2017 Jan;360(1):1-13.
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