PAT-505 ( PAT 505;PAT505 )

Catalog No. M12680 CAS No. 1782070-85-2

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Datasheet

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Product Name

PAT-505
Note

Research use only, not for human use.
Brief Description

PAT-505 (PAT 505, PAT505) is a potent, selective, noncompetitive, and orally active autotaxin inhibitor with IC50 of 2.0 nM against the lysoPLD activity of human ATX.
Description

PAT-505 (PAT 505, PAT505) is a potent, selective, noncompetitive, and orally active autotaxin inhibitor with IC50 of 2.0 nM against the lysoPLD activity of human ATX; displays high selectivity over other ENPP proteins and no significant agonist or antagonist activity at PPARα and PPARγ; maintains good potency for inhibition of lysoPLD activity with IC50 of 9.7 nM and 62 nM in human blood and mouse plasma, respectively; robustly reduces liver fibrosis with no significant effect on steatosis, hepatocellular ballooning, or inflammation in high-fat diet model of NASH.
Synonyms

PAT 505;PAT505
Pathway

Wnt/Notch/Hedgehog
Target

Autotaxin
Recptor

Autotaxin
Research Area

——
Indication

——

CAS Number

1782070-85-2
Formula Weight

495.91
Molecular Formula

C23H17ClF2N3NaO2S
Purity

>98% (HPLC)
Solubility

——
SMILES

CCN1C=C(C=N1)N2C(=C(C3=C2C(=C(C=C3)Cl)F)SC4=CC=CC(=C4F)C(=O)[O-])C5CC5.[Na+]
Chemical Name

3-((6-chloro-2-cyclopropyl-1-(1-ethyl-1H-pyrazol-4-yl)-7-fluoro-1H-indol-3-yl) thio)-2-fluorobenzoic acid sodium salt

1. Bain G, et al. J Pharmacol Exp Ther. 2017 Jan;360(1):1-13.

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