
PARP-1-IN-2
CAS No. 684234-55-7
PARP-1-IN-2( —— )
Catalog No. M35627 CAS No. 684234-55-7
PARP-1-IN-2 is a potent PARP1 inhibitor that crosses the blood-brain barrier (IC50: 149 nM).PARP-1-IN-2 showed significant antiproliferative activity against the human lung adenocarcinoma epithelial cell line A549 in cellular assays.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
2MG | 149 | In Stock |
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5MG | 235 | In Stock |
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10MG | 377 | In Stock |
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25MG | 610 | In Stock |
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50MG | 869 | In Stock |
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100MG | 1152 | In Stock |
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500MG | 2313 | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NamePARP-1-IN-2
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NoteResearch use only, not for human use.
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Brief DescriptionPARP-1-IN-2 is a potent PARP1 inhibitor that crosses the blood-brain barrier (IC50: 149 nM).PARP-1-IN-2 showed significant antiproliferative activity against the human lung adenocarcinoma epithelial cell line A549 in cellular assays.
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DescriptionPARP-1-IN-2 (compound 11g) is a potent and BBB-penetrated PARP1 inhibitor, with an IC50 of 149 nM. PARP1-IN-2 shows significantly potent anti-proliferative activity against Human lung adenocarcinoma epithelial cell line A549. PARP1-IN-2 can induce A549 cells apoptosis.
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In VitroPARP-1-IN-2 (compound 11g) (0-10 μM, 24-48 h) shows significantly potent anti-proliferative activity against A549 cells.PARP-1-IN-2 (0-10 μM, 24 h) decreases the expression of pro-caspase-3 and phosphorylated AKT, increases the expression of caspase-3, caspase-9 protein and the cleaved PARP-1.Cell Proliferation Assay Cell Line:A549, HFF cellsConcentration:0, 0.1, 1, 10 μM Incubation Time:24, 48 h Result:Showed significantly potent anti-proliferative activity against A549 cells, and didn’t display any significant cytotoxicity on HFF cells.Western Blot Analysis Cell Line:A549 cells Concentration:0, 0.1, 1, 10 μM Incubation Time:24 h Result: Reduced expression of pro-caspase-3 and phosphorylated AKT, significantly increased the expression of caspase-3 and caspase-9 protein, and enhanced expression of the cleaved PARP-1.
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetPARP
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RecptorPARP
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Research Area——
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Indication——
Chemical Information
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CAS Number684234-55-7
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Formula Weight424.28
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Molecular FormulaC22H15Cl2N3O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 83.33 mg/mL (196.40 mM; Ultrasonic )
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SMILESClc1ccc(cc1)-c1nn(CC(=O)Nc2cccc(Cl)c2)c(=O)c2ccccc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Almahli H, et al. Development of novel synthesized phthalazinone-based PARP-1 inhibitors with apoptosis inducing mechanism in lung cancer. Bioorg Chem. 2018 Apr;77:443-456.?
molnova catalog



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