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MK-4827 hydrochloride

CAS No. 1038915-64-8

MK-4827 hydrochloride( Niraparib hydrochloride | MK 4827 hydrochloride | MK4827 hydrochloride )

Catalog No. M10195 CAS No. 1038915-64-8

A highly potent PARP inhibitor with IC50 of 3.8 nM/2.1 nM for PARP1/PARP2.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 58 In Stock
2MG 32 In Stock
5MG 52 In Stock
10MG 76 In Stock
25MG 113 In Stock
50MG 137 In Stock
100MG 212 In Stock
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Biological Information

  • Product Name
    MK-4827 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    A highly potent PARP inhibitor with IC50 of 3.8 nM/2.1 nM for PARP1/PARP2.
  • Description
    A highly potent PARP inhibitor with IC50 of 3.8 nM/2.1 nM for PARP1/PARP2; inhibits PARP activity with EC50=4 nM in a whole cell assay, and inhibits proliferation of cancer cells with mutant BRCA-1 and BRCA-2 with CC50 in the 10 100 nM range; well tolerated in vivo and demonstrates efficacy as a single agent in a xenograft model of BRCA-1 deficient cancer.Ovarian Cancer Approved.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Niraparib hydrochloride | MK 4827 hydrochloride | MK4827 hydrochloride
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    PARP
  • Recptor
    PARP
  • Research Area
    Cancer
  • Indication
    Ovarian Cancer

Chemical Information

  • CAS Number
    1038915-64-8
  • Formula Weight
    356.8492
  • Molecular Formula
    C19H21ClN4O
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    C1CC(CNC1)C2=CC=C(C=C2)N3C=C4C=CC=C(C4=N3)C(=O)N.Cl
  • Chemical Name
    2H-Indazole-7-carboxamide, 2-[4-(3S)-3-piperidinylphenyl]-, hydrochloride (1:1)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Jones P, et al. J Med Chem. 2009 Nov 26;52(22):7170-85. 2. Bridges KA, et al. Oncotarget. 2014 Jul 15;5(13):5076-86. 3. Mirza MR, et al. N Engl J Med. 2016 Dec 1;375(22):2154-2164.
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