Ochromycinone

Research use only, not for human use.

STA-21 is a selective STAT3 inhibitor.

STA-21 is a promising STAT-3 inhibitor that reciprocally regulates Th17 and Treg cells, inhibits osteoclastogenesis in mice and humans and alleviates autoimmune inflammation in an experimental model of rheumatoid arthritis. STA-21 improved the clinical course of arthritis in IL-1Ra-KO mice. It increased not only the number of Treg cells but also the function of the Treg cells. It also suppressed Th17 cells and osteoclast formation. These data suggest that STA-21 might be an effective treatment for patients with RA.

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STA21 | Ochromycinone | NSC 628869

Cytoskeleton/Cell Adhesion Molecules

HSP

STAT3

Inflammation/Immunology

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111540-00-2

306.31

C19H14O4

>98% (HPLC)

In Vitro:?DMSO : 16.67 mg/mL (54.42 mM)

CC1CC2=C(C(=O)C1)C3=C(C=C2)C(=O)C4=C(C3=O)C=CC=C4O

8-hydroxy-3-methyl-3,4-dihydrotetraphene-1,7,12(2H)-trione

(-20℃)

With Ice Pack

≥ 2 years