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OBX02-011
CAS No. 2349336-18-9
OBX02-011 ( —— )
Catalog No. M28999 CAS No. 2349336-18-9
OBX02-011 is an effective and reversible inhibitor of EGFR tyrosine kinase with IC50s of 0.134 and 2.09 nM for triple mutants Del19/T790M/C797S and L858R/T790M/C797S.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 424 | Get Quote |
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| 10MG | 635 | Get Quote |
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| 25MG | 1143 | Get Quote |
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| 50MG | 1715 | Get Quote |
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| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameOBX02-011
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NoteResearch use only, not for human use.
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Brief DescriptionOBX02-011 is an effective and reversible inhibitor of EGFR tyrosine kinase with IC50s of 0.134 and 2.09 nM for triple mutants Del19/T790M/C797S and L858R/T790M/C797S.
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DescriptionOBX02-011 is an effective and reversible inhibitor of EGFR tyrosine kinase with IC50s of 0.134 and 2.09 nM for triple mutants Del19/T790M/C797S and L858R/T790M/C797S.(In Vitro):OBX02-011 shows broad activity at low nanomolar concentrations against mutant EGFRs. OBX02-011 occupies the ATP-binding site in a similar manner to WZ-4002.(In Vivo):In transgenic mouse models, OBX02-011 (25 mg/kg, i. p.) effectively inhibits tumor growth and EGFR activity and leads to enhanced survival.
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Synonyms——
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PathwayAngiogenesis
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TargetEGFR
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RecptorEGFR
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Research Area——
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Indication——
Chemical Information
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CAS Number2349336-18-9
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Formula Weight615.2
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Molecular FormulaC29H39ClN8O3S
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Purity>98% (HPLC)
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Solubility——
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SMILESO=S(=O)(N(C=1C=CC=CC1NC2=NC(=NC=C2Cl)NC3=CC=C(C=C3OC)N4CCC(N5CCN(C)CC5)CC4)C)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog
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