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OBX02-011

CAS No. 2349336-18-9

OBX02-011 ( —— )

Catalog No. M28999 CAS No. 2349336-18-9

OBX02-011 is an effective and reversible inhibitor of EGFR tyrosine kinase with IC50s of 0.134 and 2.09 nM for triple mutants Del19/T790M/C797S and L858R/T790M/C797S.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    OBX02-011
  • Note
    Research use only, not for human use.
  • Brief Description
    OBX02-011 is an effective and reversible inhibitor of EGFR tyrosine kinase with IC50s of 0.134 and 2.09 nM for triple mutants Del19/T790M/C797S and L858R/T790M/C797S.
  • Description
    OBX02-011 is an effective and reversible inhibitor of EGFR tyrosine kinase with IC50s of 0.134 and 2.09 nM for triple mutants Del19/T790M/C797S and L858R/T790M/C797S.(In Vitro):OBX02-011 shows broad activity at low nanomolar concentrations against mutant EGFRs. OBX02-011 occupies the ATP-binding site in a similar manner to WZ-4002.(In Vivo):In transgenic mouse models, OBX02-011 (25 mg/kg, i. p.) effectively inhibits tumor growth and EGFR activity and leads to enhanced survival.
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    EGFR
  • Recptor
    EGFR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2349336-18-9
  • Formula Weight
    615.2
  • Molecular Formula
    C29H39ClN8O3S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=S(=O)(N(C=1C=CC=CC1NC2=NC(=NC=C2Cl)NC3=CC=C(C=C3OC)N4CCC(N5CCN(C)CC5)CC4)C)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

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