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UNC0631

CAS No. 1320288-19-4

UNC0631( UNC0631, UNC 0631, UNC-0631 )

Catalog No. M17245 CAS No. 1320288-19-4

UNC0631 is a effectvie histone methyltransferase G9a inhibitor (IC50=4 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 101 In Stock
10MG 177 In Stock
25MG 378 In Stock
50MG 556 In Stock
100MG 777 In Stock
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Biological Information

  • Product Name
    UNC0631
  • Note
    Research use only, not for human use.
  • Brief Description
    UNC0631 is a effectvie histone methyltransferase G9a inhibitor (IC50=4 nM).
  • Description
    UNC-0631 is a novel G9a inhibitor with excellent potency in a variety of cell lines and excellent separation of functional potency versus cell toxicity. Protein lysine methyltransferase G9a plays key roles in the transcriptional repression of a variety of genes via dimethylation of lysine 9 on histone H3 (H3K9me2) of chromatin as well as dimethylation of nonhistone proteins including tumor suppressor p53.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    UNC0631, UNC 0631, UNC-0631
  • Pathway
    Angiogenesis
  • Target
    EGFR
  • Recptor
    G9a
  • Research Area
    Others-Field
  • Indication
    ——

Chemical Information

  • CAS Number
    1320288-19-4
  • Formula Weight
    635.93
  • Molecular Formula
    C37H61N7O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 16.67 mg/mL. 26.21 mM; H2O : < 0.1 mg/mL
  • SMILES
    COc1c(OCCCN2CCCCC2)cc2nc(nc(NC3CCN(CC4CCCCC4)CC3)c2c1)N1CCCN(CC1)C(C)C
  • Chemical Name
    N-(1-(cyclohexylmethyl)piperidin-4-yl)-2-(4-isopropyl-1,4-diazepan-1-yl)-6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-amine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Liu F, et al. J Med Chem. 2011, 54(17), 6139-6150.
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