UNC0631 ( UNC0631, UNC 0631, UNC-0631 )

Catalog No. M17245 CAS No. 1320288-19-4

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Product Name

UNC0631
Note

Research use only, not for human use.
Brief Description

UNC0631 is a effectvie histone methyltransferase G9a inhibitor (IC50=4 nM).
Description

UNC-0631 is a novel G9a inhibitor with excellent potency in a variety of cell lines and excellent separation of functional potency versus cell toxicity. Protein lysine methyltransferase G9a plays key roles in the transcriptional repression of a variety of genes via dimethylation of lysine 9 on histone H3 (H3K9me2) of chromatin as well as dimethylation of nonhistone proteins including tumor suppressor p53.
Synonyms

UNC0631, UNC 0631, UNC-0631
Pathway

Angiogenesis
Target

EGFR
Recptor

G9a
Research Area

Others-Field
Indication

——

CAS Number

1320288-19-4
Formula Weight

635.93
Molecular Formula

C37H61N7O2
Purity

98%
Solubility

DMSO : 16.67 mg/mL. 26.21 mM; H2O : < 0.1 mg/mL
SMILES

COc1c(OCCCN2CCCCC2)cc2nc(nc(NC3CCN(CC4CCCCC4)CC3)c2c1)N1CCCN(CC1)C(C)C
Chemical Name

N-(1-(cyclohexylmethyl)piperidin-4-yl)-2-(4-isopropyl-1,4-diazepan-1-yl)-6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-amine

1. Liu F, et al. J Med Chem. 2011, 54(17), 6139-6150.

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