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Nonivamide

CAS No. 2444-46-4

Nonivamide ( Pseudocapsaicin;Pelargonic acid vanillylamide;Nonanoic acid vanillylamide )

Catalog No. M13707 CAS No. 2444-46-4

A capsaicin analog that acts as an agonist of TRPV1 channel.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Nonivamide
  • Note
    Research use only, not for human use.
  • Brief Description
    A capsaicin analog that acts as an agonist of TRPV1 channel.
  • Description
    A capsaicin analog that acts as an agonist of TRPV1 channel; causes calcium release from the ER and alters the transcription of GADD153, GADD45alpha, GRP78/BiP, ATF3, CCND1, and CCNG2 in human bronchial epithelial and alveolar cells; stimulates the Ca(2+)-dependent release of serotonin and dopamine in SH-SY5Y cells at 1 uM; also enhances miRNA let-7d expression and decreases adipogenesis PPARγ expression in 3T3-L1 cells.Pain Phase 3 Clinical
  • Synonyms
    Pseudocapsaicin;Pelargonic acid vanillylamide;Nonanoic acid vanillylamide
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    TRP/TRPV Channel
  • Recptor
    TRPV1
  • Research Area
    Neurological Disease
  • Indication
    Pain

Chemical Information

  • CAS Number
    2444-46-4
  • Formula Weight
    293.40
  • Molecular Formula
    C17H27NO3
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(NC(CCCCCCCC)=O)C1=CC=C(O)C(OC)=C1
  • Chemical Name
    Nonanamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Rohm B, et al. Mol Nutr Food Res. 2013 Nov;57(11):2008-18.
2. Thomas KC, et al. J Pharmacol Exp Ther. 2007 Jun;321(3):830-8.
3. Rohm B, et al. J Cell Biochem. 2015 Jun;116(6):1153-63.
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