AMG-9810

Research use only, not for human use.

A potent, selective and competitive TRPV1 antagonist with IC50 of 24.5 and 85.6 nM for human and rat TRPV1, repectively.

A potent, selective and competitive TRPV1 antagonist with IC50 of 24.5 and 85.6 nM for human and rat TRPV1, repectively; blocks capsaicin-evoked depolarization and CGRP release in cultures of rat dorsal root ganglion primary neurons; the first cinnamide TRPV1 antagonist reported to block capsaicin-induced eye wiping behavior and reverse hyperalgesia in an animal model of inflammatory pain.Pain Preclinical

AMG9810;AMG 9810

Membrane Transporter/Ion Channel

TRP/TRPV Channel

TRP/TRPV Channel

Neurological Disease

Pain

545395-94-6

337.42

C21H23NO3

>98% (HPLC)

DMSO: ≥ 33 mg/mL

CC(C)(C)c1ccc(cc1)/C=C/C(=O)Nc2ccc3c(c2)OCCO3

2-Propenamide, N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-dimethylethyl)phenyl]-, (2E)-

(-20℃)

With Ice Pack

≥ 2 years