Cart
sales@molnova.com
AMG-9810
CAS No. 545395-94-6
AMG-9810 ( AMG9810;AMG 9810 )
Catalog No. M14961 CAS No. 545395-94-6
A potent, selective and competitive TRPV1 antagonist with IC50 of 24.5 and 85.6 nM for human and rat TRPV1, repectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 39 | In Stock |
|
| 10MG | 50 | In Stock |
|
| 25MG | 106 | In Stock |
|
| 50MG | 194 | In Stock |
|
| 100MG | 339 | In Stock |
|
| 500MG | 795 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameAMG-9810
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, selective and competitive TRPV1 antagonist with IC50 of 24.5 and 85.6 nM for human and rat TRPV1, repectively.
-
DescriptionA potent, selective and competitive TRPV1 antagonist with IC50 of 24.5 and 85.6 nM for human and rat TRPV1, repectively; blocks capsaicin-evoked depolarization and CGRP release in cultures of rat dorsal root ganglion primary neurons; the first cinnamide TRPV1 antagonist reported to block capsaicin-induced eye wiping behavior and reverse hyperalgesia in an animal model of inflammatory pain.Pain Preclinical
-
SynonymsAMG9810;AMG 9810
-
PathwayMembrane Transporter/Ion Channel
-
TargetTRP/TRPV Channel
-
RecptorTRP/TRPV Channel
-
Research AreaNeurological Disease
-
IndicationPain
Chemical Information
-
CAS Number545395-94-6
-
Formula Weight337.42
-
Molecular FormulaC21H23NO3
-
Purity>98% (HPLC)
-
SolubilityDMSO: ≥ 33 mg/mL
-
SMILESCC(C)(C)c1ccc(cc1)/C=C/C(=O)Nc2ccc3c(c2)OCCO3
-
Chemical Name2-Propenamide, N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-dimethylethyl)phenyl]-, (2E)-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Gavva NR, et al. J Pharmacol Exp Ther. 2005 Apr;313(1):474-84.
2. Gavva NR, et al. J Neurosci. 2007 Mar 28;27(13):3366-74.
3. Peles S, et al. Neuroscience. 2009 Jun 30;161(2):515-25.
2. Gavva NR, et al. J Neurosci. 2007 Mar 28;27(13):3366-74.
3. Peles S, et al. Neuroscience. 2009 Jun 30;161(2):515-25.
molnova catalog
related products
-
A-967079
A potent, selective TRPA1 channel blocker with IC50 of 51 nM and 101 nM for hTRPA1 and rTRPA1, respectively.
-
n-Butylidenephthalid...
(Z)-3-butylidenephthalide has antihyperglycemic effect is due to inhibition of α-glucosidase at the intestinal level, inhibited the activity of yeast-α-glucosidase (IC(5) 2.35 mM) in a noncompetitive fashion with a K(i) of 4.86 mM.
-
Mesendogen
Mesendogen is an inhibitor of transient receptor potential cation channel, subfamily M, member 6 (TRPM6) and 7 (TRPM7) and acts by inhibiting TRPM6/TRPM7 magnesium channel activity.
