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MK-8591
CAS No. 865363-93-5
MK-8591( Islatravir | MK8591 | EFdA )
Catalog No. M16284 CAS No. 865363-93-5
MK-8591 (Islatravir, MK8591, EFdA) is a nucleoside analog that exhibits remarkable potency against wild-type and drug-resistant HIVs.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 181 | In Stock |
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| 5MG | 164 | In Stock |
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| 10MG | 259 | In Stock |
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| 25MG | 454 | In Stock |
|
| 50MG | 603 | In Stock |
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| 100MG | 809 | In Stock |
|
| 200MG | 1088 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMK-8591
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NoteResearch use only, not for human use.
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Brief DescriptionMK-8591 (Islatravir, MK8591, EFdA) is a nucleoside analog that exhibits remarkable potency against wild-type and drug-resistant HIVs.
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DescriptionMK-8591 (Islatravir, MK8591, EFdA) is a nucleoside analog that exhibits remarkable potency against wild-type and drug-resistant HIVs, inhibits HIV-1 reverse transcriptase with multiple mechanisms; also retains potent activity against multinucleoside-resistant HIV-2 mutants (EC50<11 nM).HIV Infection Phase 2 Clinical.
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In VitroIslatravir (MK-8591) (4'Ed2FA) is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC50s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively.
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In Vivo——
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SynonymsIslatravir | MK8591 | EFdA
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PathwayMicrobiology/Virology
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TargetHIV
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RecptorHIV
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Research AreaInfection
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IndicationHIV Infection
Chemical Information
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CAS Number865363-93-5
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Formula Weight293.25
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Molecular FormulaC12H12FN5O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (341.01 mM)
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SMILESNC1=C(N=CN2[C@H]3C[C@@H]([C@@](O3)(C#C)CO)O)C2=NC(F)=N1
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Chemical Name(2R,3S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-2-ethynyl-2-(hydroxymethyl)tetrahydrofuran-3-ol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wu VH, et al. Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00744-17.
2. Salie ZL, et al. Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):9274-9.
3. Michailidis E, et al. J Biol Chem. 2014 Aug 29;289(35):24533-48.
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