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Necrostatin-5

CAS No. 337349-54-9

Necrostatin-5( —— )

Catalog No. M34958 CAS No. 337349-54-9

Necrostatin-5 (Nec-5) is a selective RIP1 kinase inhibitor and cell necrosis inhibitor that prevents the death of Fadd-deficient Jurkat cells treated with TNF-α, with an EC50 of 240 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Necrostatin-5
  • Note
    Research use only, not for human use.
  • Brief Description
    Necrostatin-5 (Nec-5) is a selective RIP1 kinase inhibitor and cell necrosis inhibitor that prevents the death of Fadd-deficient Jurkat cells treated with TNF-α, with an EC50 of 240 nM.
  • Description
    Necrostatin-5 (Nec-5) is a potent necroptosis inhibitor with an EC50 value of 0.24 μM. Necrostatin-5 also is a RIP1 inhibitor. Necrostatin-5 shows cardioprotective effects.
  • In Vitro
    ——
  • In Vivo
    Animal Model:200-300 g, male Wistar rats Dosage:2.46 mg/kg Administration:I.p.; 60 min before experiment Result:Reduced the infarction zone caused by 30-min global ischemia and 120-min reperfusion.
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    RIP kinase
  • Recptor
    RIP kinase | Necroptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    337349-54-9
  • Formula Weight
    383.49
  • Molecular Formula
    C19H17N3O2S2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 5 mg/mL (13.04 mM; Ultrasonic (<60°C)
  • SMILES
    O=C1C=2C3=C(SC2N=C(SCC#N)N1C4=CC=C(OC)C=C4)CCCC3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wang K, et al. Structure-activity relationship analysis of a novel necroptosis inhibitor, Necrostatin-5. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1455-65. ?
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