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NecroX-7
CAS No. 1120333-38-1
NecroX-7( Necrosis inhibitor 7 )
Catalog No. M10431 CAS No. 1120333-38-1
NecroX-7 is a small molecule necrosis modulator and potent antioxidant molecule.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameNecroX-7
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NoteResearch use only, not for human use.
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Brief DescriptionNecroX-7 is a small molecule necrosis modulator and potent antioxidant molecule.
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DescriptionNecroX-7 is a small molecule necrosis modulator and potent antioxidant molecule, which can be bound to some types of radicals and especially NAPQI; inhibits osteoclast differentiation by suppressing NF-κB activity and c-Fos expression, reduces hepatic necrosis secondary to IR injury in vivo; decreases t-BHP- and APAP-induced cell death and ROS/RNS formation in HepG2 human hepatocarcinoma and primary mouse hepatocytes, also protects mice from APAP-induced liver injury and lethality by binding directly to NAPQI.
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In Vitro——
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In Vivo——
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SynonymsNecrosis inhibitor 7
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number1120333-38-1
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Formula Weight439.574
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Molecular FormulaC24H29N3O3S
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name4-((7-((1-(methylsulfonyl)piperidin-4-yl)amino)-2-phenyl-1H-indol-5-yl)methyl)thiomorpholine 1,1-dioxide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Choi JM, et al. Transplant Proc. 2010 Nov;42(9):3414-21.
2. Grootaert MO, et al. Atherosclerosis. 2016 Sep;252:166-74.
3. Lee DW, et al. Am J Physiol Heart Circ Physiol. 2011 Sep;301(3):H1004-14.
4. Park JH, et al. Antioxid Redox Signal. 2013 May 10;18(14):1713-22.
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