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NecroX-7

CAS No. 1120333-38-1

NecroX-7( Necrosis inhibitor 7 )

Catalog No. M10431 CAS No. 1120333-38-1

NecroX-7 is a small molecule necrosis modulator and potent antioxidant molecule.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    NecroX-7
  • Note
    Research use only, not for human use.
  • Brief Description
    NecroX-7 is a small molecule necrosis modulator and potent antioxidant molecule.
  • Description
    NecroX-7 is a small molecule necrosis modulator and potent antioxidant molecule, which can be bound to some types of radicals and especially NAPQI; inhibits osteoclast differentiation by suppressing NF-κB activity and c-Fos expression, reduces hepatic necrosis secondary to IR injury in vivo; decreases t-BHP- and APAP-induced cell death and ROS/RNS formation in HepG2 human hepatocarcinoma and primary mouse hepatocytes, also protects mice from APAP-induced liver injury and lethality by binding directly to NAPQI.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Necrosis inhibitor 7
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1120333-38-1
  • Formula Weight
    439.574
  • Molecular Formula
    C24H29N3O3S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    4-((7-((1-(methylsulfonyl)piperidin-4-yl)amino)-2-phenyl-1H-indol-5-yl)methyl)thiomorpholine 1,1-dioxide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Choi JM, et al. Transplant Proc. 2010 Nov;42(9):3414-21. 2. Grootaert MO, et al. Atherosclerosis. 2016 Sep;252:166-74. 3. Lee DW, et al. Am J Physiol Heart Circ Physiol. 2011 Sep;301(3):H1004-14. 4. Park JH, et al. Antioxid Redox Signal. 2013 May 10;18(14):1713-22.
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