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LCH-7749944

CAS No. 796888-12-5

LCH-7749944 ( GNF-PF-2356 )

Catalog No. M22466 CAS No. 796888-12-5

LCH-7749944 effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis.?

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    LCH-7749944
  • Note
    Research use only, not for human use.
  • Brief Description
    LCH-7749944 effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis.?
  • Description
    LCH-7749944 effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis.?LCH-7749944 is a potent PAK4 inhibitor with an IC50 of 14.93 μM.?LCH-7749944 (5-20 μM; 12-48 hours) prominently induces a dose-dependent increase in the percentage of cells in G1 phase and decrease in S phase. ?LCH-7749944 (5-30 μM; 24 hours) dramatically decreases levels of phosphoPAK4, phospho-c-Src, phospho-EGFR and cyclin D1 protein expression in a dose-dependent manner.?LCH-7749944 (GNF-PF-2356;?5-50 μM;?24 hours) inhibits the proliferation of MKN-1, BGC823, SGC7901 and MGC803 cells in a concentration dependent manner.??LCH-7749944 (5-20 μM;?12-48 hours) induces apoptosis of SGC7901 cells.??
  • Synonyms
    GNF-PF-2356
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    PAK4;apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    796888-12-5
  • Formula Weight
    350.41
  • Molecular Formula
    C20H22N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:250 mg/mL (713.45 mM; Need ultrasonic)
  • SMILES
    COc1cccc(Nc2nc(NCC3CCCO3)c3ccccc3n2)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zhang J, et al. LCH-7749944, a novel and potent p21-activated kinase 4 inhibitor, suppresses proliferation and invasion in human gastric cancer cells. Cancer Lett. 2012 Apr 1;317(1):24-32.
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