Clovamide
CAS No. 53755-02-5
Clovamide ( N-trans-Caffeoy-L-dopa; trans-Clovamide )
Catalog No. M27835 CAS No. 53755-02-5
Trans-Clovamide is a naturally occurring caffeoyl conjugate identified in the antioxidant polyphenolic fraction of cocoa (T. cacao L.) Trans-Clovamide is a potent antioxidantand that has shown neuroprotective effects (EC50s = 0.9-3.7 μM) in several in vitro models of neuronal death.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 31 | Get Quote |
|
5MG | 50 | Get Quote |
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10MG | 80 | Get Quote |
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25MG | 125 | Get Quote |
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50MG | 222 | Get Quote |
|
100MG | 380 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
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Biological Information
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Product NameClovamide
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NoteResearch use only, not for human use.
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Brief DescriptionTrans-Clovamide is a naturally occurring caffeoyl conjugate identified in the antioxidant polyphenolic fraction of cocoa (T. cacao L.) Trans-Clovamide is a potent antioxidantand that has shown neuroprotective effects (EC50s = 0.9-3.7 μM) in several in vitro models of neuronal death.
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DescriptionTrans-Clovamide is a naturally occurring caffeoyl conjugate identified in the antioxidant polyphenolic fraction of cocoa (T. cacao L.) Trans-Clovamide is a potent antioxidantand that has shown neuroprotective effects (EC50s = 0.9-3.7 μM) in several in vitro models of neuronal death. Trans-Clovamide is an excellent ROS and oxygen radical scavenger and also has anti-inflammatory and neuroprotective effects. Clovamide is an anti-microbial with activity against the human pathogens influenza A subtype H5N1, Trypanosoma evansi, and Heliobacter pylori.(In Vitro):Clovamide protects neurons from injury in three in vitro models of neuronal death: oxidative stress, excitotoxicity and OGD/reoxygenation. In SH-SY5Y human neuroblastoma cells, Clovamide (10-100 μM) protects cell death significantly with an EC50 value of 3.6 μM. Clovamide inhibits growth of three pathogens of cacao in the genus?Phytophthora, is a substrate for cacao polyphenol oxidase, and is a contributor to enzymatic browning. Clovamide inhibits proteinase and pectinase in vitro. Clovamide also enhances PPARγ expression.
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SynonymsN-trans-Caffeoy-L-dopa; trans-Clovamide
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PathwayApoptosis
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TargetApoptosis
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RecptorHuman Endogenous Metabolite
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Research Area——
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Indication——
Chemical Information
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CAS Number53755-02-5
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Formula Weight359.3
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Molecular FormulaC18H17NO7
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Purity>98% (HPLC)
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Solubility——
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SMILESOC(=O)[C@H](Cc1ccc(O)c(O)c1)NC(=O)\C=C\c1ccc(O)c(O)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Nilasha Banerjee, et al. Estrone-3-sulphate, a potential novel ligand for targeting breast cancers. PLoS One. 2013 May 22;8(5):e64069.
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