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Clovamide

CAS No. 53755-02-5

Clovamide( N-trans-Caffeoy-L-dopa | trans-Clovamide )

Catalog No. M27835 CAS No. 53755-02-5

Trans-Clovamide is a naturally occurring caffeoyl conjugate identified in the antioxidant polyphenolic fraction of cocoa (T. cacao L.) Trans-Clovamide is a potent antioxidantand that has shown neuroprotective effects (EC50s = 0.9-3.7 μM) in several in vitro models of neuronal death.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Clovamide
  • Note
    Research use only, not for human use.
  • Brief Description
    Trans-Clovamide is a naturally occurring caffeoyl conjugate identified in the antioxidant polyphenolic fraction of cocoa (T. cacao L.) Trans-Clovamide is a potent antioxidantand that has shown neuroprotective effects (EC50s = 0.9-3.7 μM) in several in vitro models of neuronal death.
  • Description
    Trans-Clovamide is a naturally occurring caffeoyl conjugate identified in the antioxidant polyphenolic fraction of cocoa (T. cacao L.) Trans-Clovamide is a potent antioxidantand that has shown neuroprotective effects (EC50s = 0.9-3.7 μM) in several in vitro models of neuronal death. Trans-Clovamide is an excellent ROS and oxygen radical scavenger and also has anti-inflammatory and neuroprotective effects. Clovamide is an anti-microbial with activity against the human pathogens influenza A subtype H5N1, Trypanosoma evansi, and Heliobacter pylori.(In Vitro):Clovamide protects neurons from injury in three in vitro models of neuronal death: oxidative stress, excitotoxicity and OGD/reoxygenation. In SH-SY5Y human neuroblastoma cells, Clovamide (10-100 μM) protects cell death significantly with an EC50 value of 3.6 μM. Clovamide inhibits growth of three pathogens of cacao in the genus?Phytophthora, is a substrate for cacao polyphenol oxidase, and is a contributor to enzymatic browning. Clovamide inhibits proteinase and pectinase in vitro. Clovamide also enhances PPARγ expression.
  • In Vitro
    Clovamide is able to protect neurons from injury in three in vitro models of neuronal death: oxidative stress, excitotoxicity and OGD/reoxygenation. In SH-SY5Y human neuroblastoma cells, Clovamide (10-100 μM) significantly protects cell death, with an EC50 value of 3.6 μM. Clovamide also significantly enhances PPARγ expression.Clovamide inhibits growth of three pathogens of cacao in the genus Phytophthora, is a substrate for cacao polyphenol oxidase, and is a contributor to enzymatic browning. Clovamide inhibiteds proteinase and pectinase in vitro.
  • In Vivo
    ——
  • Synonyms
    N-trans-Caffeoy-L-dopa | trans-Clovamide
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Human Endogenous Metabolite
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    53755-02-5
  • Formula Weight
    359.334
  • Molecular Formula
    C18H17NO7
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (347.87 mM)
  • SMILES
    OC(=O)[C@H](Cc1ccc(O)c(O)c1)NC(=O)\C=C\c1ccc(O)c(O)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Nilasha Banerjee, et al. Estrone-3-sulphate, a potential novel ligand for targeting breast cancers. PLoS One. 2013 May 22;8(5):e64069.
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