Cart
sales@molnova.com
Home - Products - Apoptosis - Apoptosis - Clovamide

Clovamide

CAS No. 53755-02-5

Clovamide( N-trans-Caffeoy-L-dopa | trans-Clovamide )

Catalog No. M27835 CAS No. 53755-02-5

Trans-Clovamide is a naturally occurring caffeoyl conjugate identified in the antioxidant polyphenolic fraction of cocoa (T. cacao L.) Trans-Clovamide is a potent antioxidantand that has shown neuroprotective effects (EC50s = 0.9-3.7 μM) in several in vitro models of neuronal death.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 31 Get Quote
5MG 50 Get Quote
10MG 80 Get Quote
25MG 125 Get Quote
50MG 222 Get Quote
100MG 380 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Clovamide
  • Note
    Research use only, not for human use.
  • Brief Description
    Trans-Clovamide is a naturally occurring caffeoyl conjugate identified in the antioxidant polyphenolic fraction of cocoa (T. cacao L.) Trans-Clovamide is a potent antioxidantand that has shown neuroprotective effects (EC50s = 0.9-3.7 μM) in several in vitro models of neuronal death.
  • Description
    Trans-Clovamide is a naturally occurring caffeoyl conjugate identified in the antioxidant polyphenolic fraction of cocoa (T. cacao L.) Trans-Clovamide is a potent antioxidantand that has shown neuroprotective effects (EC50s = 0.9-3.7 μM) in several in vitro models of neuronal death. Trans-Clovamide is an excellent ROS and oxygen radical scavenger and also has anti-inflammatory and neuroprotective effects. Clovamide is an anti-microbial with activity against the human pathogens influenza A subtype H5N1, Trypanosoma evansi, and Heliobacter pylori.(In Vitro):Clovamide protects neurons from injury in three in vitro models of neuronal death: oxidative stress, excitotoxicity and OGD/reoxygenation. In SH-SY5Y human neuroblastoma cells, Clovamide (10-100 μM) protects cell death significantly with an EC50 value of 3.6 μM. Clovamide inhibits growth of three pathogens of cacao in the genus?Phytophthora, is a substrate for cacao polyphenol oxidase, and is a contributor to enzymatic browning. Clovamide inhibits proteinase and pectinase in vitro. Clovamide also enhances PPARγ expression.
  • In Vitro
    Clovamide is able to protect neurons from injury in three in vitro models of neuronal death: oxidative stress, excitotoxicity and OGD/reoxygenation. In SH-SY5Y human neuroblastoma cells, Clovamide (10-100 μM) significantly protects cell death, with an EC50 value of 3.6 μM. Clovamide also significantly enhances PPARγ expression.Clovamide inhibits growth of three pathogens of cacao in the genus Phytophthora, is a substrate for cacao polyphenol oxidase, and is a contributor to enzymatic browning. Clovamide inhibiteds proteinase and pectinase in vitro.
  • In Vivo
    ——
  • Synonyms
    N-trans-Caffeoy-L-dopa | trans-Clovamide
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Human Endogenous Metabolite
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    53755-02-5
  • Formula Weight
    359.334
  • Molecular Formula
    C18H17NO7
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (347.87 mM)
  • SMILES
    OC(=O)[C@H](Cc1ccc(O)c(O)c1)NC(=O)\C=C\c1ccc(O)c(O)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Nilasha Banerjee, et al. Estrone-3-sulphate, a potential novel ligand for targeting breast cancers. PLoS One. 2013 May 22;8(5):e64069.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • (E/Z)-E64FC26

    (E/Z)-E64FC26 is a potent protein disulfide isomerase (PDI) family inhibitor with potential antitumor activity and affinity for PDIA1, PDIA3, PDIA4, TXNDC5 and PDIA6. (E/Z)-E64FC26 can be used for myeloma research.

  • Soyasapogenol B

    Soyasapogenol B has anti-cancer, hypocholesterolemic, anticomplementary, hepatoprotective effects, it inhibits proliferation of cultured Hep-G2.

  • (R)-Isomucronulatol

    (R)-Isomucronulatol (2H-1-Benzopyran-7-ol), a flavonoid that can be extracted from the leaves of Astragalus membranaceus, Sophora japonica, Sclerotium tigrinum, and Glycyrrhiza glabra, inhibits the proliferation and apoptosis of BMSCs in the TNF-α microenvironment.

Sign In Join Free