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NWL-117

CAS No. ——

NWL-117( NWL117 | NWL 117 )

Catalog No. M16926 CAS No. ——

A potent Caspase-6 inhibitor with IC50 of 192 nM, also inhibits Caspase-4/8/9/10 with IC50 of 0.1-0.8 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    NWL-117
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent Caspase-6 inhibitor with IC50 of 192 nM, also inhibits Caspase-4/8/9/10 with IC50 of 0.1-0.8 uM.
  • Description
    A potent Caspase-6 inhibitor with IC50 of 192 nM, also inhibits Caspase-4/8/9/10 with IC50 of 0.1-0.8 uM; shows weak activity against other Capase subutypes; inhibits Caspase-6 in Caspase-6-transfected HCT116 cells with IC50 of 4.82 uM; inhibits serum deprivation-induced Caspase-6 activity and prevents amyloid precursor protein-mediated neurite degeneration in human primary CNS neurons; BBB penetrant.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    NWL117 | NWL 117
  • Pathway
    Apoptosis
  • Target
    Caspase
  • Recptor
    Caspase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    ——
  • Formula Weight
    654.732
  • Molecular Formula
    C29H42N4O11S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(O)[C@@H](/C=C/S(=O)(C)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CCC(O)=O)NC([C@H](C(C)C)NC(OCC1=CC=CC=C1)=O)=O)=O)=O
  • Chemical Name
    (5S,8S,11S,14R)-11-((S)-sec-butyl)-8-(2-carboxyethyl)-5-isopropyl-14-((E)-2-(methylsulfonyl)vinyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazapentadecan-15-oic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Pakavathkumar P, et al. Mol Neurodegener. 2017 Feb 28;12(1):22.
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