PAC1 ( Procaspase-activating Compound 1 )

Catalog No. M14020 CAS No. 315183-21-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

PAC1
Note

Research use only, not for human use.
Brief Description

PAC-1 is a potent procaspase-3 activator with EC50 of 0.22 μM and the first small molecule known to directly activate procaspase-3 to caspase-3.
Description

PAC-1 is a potent procaspase-3 activator with EC50 of 0.22 μM and the first small molecule known to directly activate procaspase-3 to caspase-3.
Synonyms

Procaspase-activating Compound 1
Pathway

Apoptosis
Target

Caspase
Recptor

Procaspase-3
Research Area

Cancer
Indication

——

CAS Number

315183-21-2
Formula Weight

392.49
Molecular Formula

C23H28N4O2
Purity

>98%(HPLC)
Solubility

Ethanol: 16 mg/mL (40.76 mM); DMSO: 78 mg/mL (198.73 mM)
SMILES

O=C(N/N=C/C1=CC=CC(CC=C)=C1O)CN2CCN(CC3=CC=CC=C3)CC2
Chemical Name

(E)-N'-(3-allyl-2-hydroxybenzylidene)-2-(4-benzylpiperazin-1-yl)acetohydrazide

1. Putt KS, et al. nat Chem Biol, 2006, 2(10), 543-550.

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