
Selamectin
CAS No. 220119-17-5
Selamectin( Selamectin | Revolution | Stronghold )
Catalog No. M18249 CAS No. 220119-17-5
Selamectin is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes.
Purity : >98% (HPLC)






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Biological Information
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Product NameSelamectin
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NoteResearch use only, not for human use.
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Brief DescriptionSelamectin is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes.
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DescriptionSelamectin is a topical parasiticide and anthelminthic used on dogs and cats. It treats and prevents infections of heartworms, fleas, ear mites, sarcoptic mange (scabies), and certain types of ticks in dogs, and prevents heartworms, fleas, ear mites, hookworms, and roundworms in cats.(In Vitro):The transport of radiolabelled Selamectin through Caco-2 monolayers shows that Selamectin is P-glycoprotein (P-gp) substrates with a secretory/absorptive ratio of 4.7. Selamectin inhibits the efflux of Rh-123 from peripheral blood lymphocytes (PBL) and the concentration of inhibition is similar to that of Verapamil.(In Vivo):A single administration of 6 mg/kg topical Selamectin given every two months could effectively prevent B. malayi infection in cats. Application of topical Selamectin twice a year could block circulating microfilariae.
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In VitroThe transport of radiolabelled Selamectin through Caco-2 monolayers shows that Selamectin is P-glycoprotein (P-gp) substrates with a secretory/absorptive ratio of 4.7. Selamectin inhibits the efflux of Rh-123 from peripheral blood lymphocytes (PBL) and the concentration of inhibition is similar to that of Verapamil.
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In VivoA single administration of 6 mg/kg topical Selamectin given every two months could effectively prevent B. malayi infection in cats. Application of topical Selamectin twice a year could block circulating microfilariae.
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SynonymsSelamectin | Revolution | Stronghold
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PathwayApoptosis
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TargetCaspase
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RecptorOthers
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Research AreaOthers-Field
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Indication——
Chemical Information
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CAS Number220119-17-5
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Formula Weight769.96
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Molecular FormulaC43H63NO11
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Purity>98% (HPLC)
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SolubilityDMSO : 100 mg/mL 129.88 mM
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SMILESC/C/1=C\C[C@@H]2C[C@H](OC(=O)[C@H]3[C@@]4(/C(=C/C=C/[C@@H]([C@@H]1O[C@H]1C[C@H](OC)[C@@H](O)[C@H](C)O1)C)/CO[C@@H]4/C(=N\O)/C(=C3)C)O)C[C@]1(CC[C@H](C)[C@@H](C3CCCCC3)O1)O2
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Chemical NameA name could not be generated for this structure.
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Holden-Dye, L. , et al. Anthelmintic drugs and nematicides: Studies in Caenorhabditis elegans. WormBook 16, (2014).
molnova catalog



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