Selamectin

CAS No. 220119-17-5

Selamectin( Selamectin | Revolution | Stronghold )

Catalog No. M18249 CAS No. 220119-17-5

Selamectin is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 76 In Stock
25MG 160 In Stock
50MG 267 In Stock
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Biological Information

  • Product Name
    Selamectin
  • Note
    Research use only, not for human use.
  • Brief Description
    Selamectin is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes.
  • Description
    Selamectin is a topical parasiticide and anthelminthic used on dogs and cats. It treats and prevents infections of heartworms, fleas, ear mites, sarcoptic mange (scabies), and certain types of ticks in dogs, and prevents heartworms, fleas, ear mites, hookworms, and roundworms in cats.(In Vitro):The transport of radiolabelled Selamectin through Caco-2 monolayers shows that Selamectin is P-glycoprotein (P-gp) substrates with a secretory/absorptive ratio of 4.7. Selamectin inhibits the efflux of Rh-123 from peripheral blood lymphocytes (PBL) and the concentration of inhibition is similar to that of Verapamil.(In Vivo):A single administration of 6 mg/kg topical Selamectin given every two months could effectively prevent B. malayi infection in cats. Application of topical Selamectin twice a year could block circulating microfilariae.
  • In Vitro
    The transport of radiolabelled Selamectin through Caco-2 monolayers shows that Selamectin is P-glycoprotein (P-gp) substrates with a secretory/absorptive ratio of 4.7. Selamectin inhibits the efflux of Rh-123 from peripheral blood lymphocytes (PBL) and the concentration of inhibition is similar to that of Verapamil.
  • In Vivo
    A single administration of 6 mg/kg topical Selamectin given every two months could effectively prevent B. malayi infection in cats. Application of topical Selamectin twice a year could block circulating microfilariae.
  • Synonyms
    Selamectin | Revolution | Stronghold
  • Pathway
    Apoptosis
  • Target
    Caspase
  • Recptor
    Others
  • Research Area
    Others-Field
  • Indication
    ——

Chemical Information

  • CAS Number
    220119-17-5
  • Formula Weight
    769.96
  • Molecular Formula
    C43H63NO11
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 100 mg/mL 129.88 mM
  • SMILES
    C/C/1=C\C[C@@H]2C[C@H](OC(=O)[C@H]3[C@@]4(/C(=C/C=C/[C@@H]([C@@H]1O[C@H]1C[C@H](OC)[C@@H](O)[C@H](C)O1)C)/CO[C@@H]4/C(=N\O)/C(=C3)C)O)C[C@]1(CC[C@H](C)[C@@H](C3CCCCC3)O1)O2
  • Chemical Name
    A name could not be generated for this structure.

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Holden-Dye, L. , et al. Anthelmintic drugs and nematicides: Studies in Caenorhabditis elegans. WormBook 16, (2014).
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