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NVP-TNKS656

CAS No. 1419949-20-4

NVP-TNKS656( NVPTNKS656 | TNKS656 | TNKS656 )

Catalog No. M17287 CAS No. 1419949-20-4

NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    NVP-TNKS656
  • Note
    Research use only, not for human use.
  • Brief Description
    NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor.
  • Description
    NVP-TNKS656, also known as TNKS656, is a potent and orally active Tankyrase Inhibitor. With an enthalpy-driven thermodynamic signature of binding, highly favorable physicochemical properties, and high lipophilic efficiency, NVP-TNKS656 is well suited for further in vivo validation studies. Bioactivity of TNKS656: TNKS2 IC50 = 6nM, LiPE = 7.0, HEK298 STF IC50 = 3.5nM, Cmax/ Cellular IC50 = 23,000.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    NVPTNKS656 | TNKS656 | TNKS656
  • Pathway
    Neuroscience
  • Target
    Gamma-secretase
  • Recptor
    TNKS2
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1419949-20-4
  • Formula Weight
    494.58
  • Molecular Formula
    C27H34N4O5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 40 mg/mL. 80.88 mM
  • SMILES
    COc1ccc(cc1)C(=O)C1CCN(CC(=O)N(CC2CC2)Cc2nc(=O)c3c(CCOC3)[nH]2)CC1
  • Chemical Name
    N-(cyclopropylmethyl)-2-(4-(4-methoxybenzoyl)piperidin-1-yl)-N-((4-oxo-4,5,7,8-tetrahydro-3H-pyrano[4,3-d]pyrimidin-2-yl)methyl)acetamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Shultz MD, et al. J Med Chem. 2013, 56(16), 6495-6511.
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