
NVP-BVU972
CAS No. 1185763-69-2
NVP-BVU972( NVP-BVU972 | NVP-BVU 972 | NVP-BVU-972 )
Catalog No. M17175 CAS No. 1185763-69-2
NVP-BVU972 is a selective and potent Met inhibitor with IC50 of 14 nM.
Purity : >98% (HPLC)






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Biological Information
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Product NameNVP-BVU972
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NoteResearch use only, not for human use.
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Brief DescriptionNVP-BVU972 is a selective and potent Met inhibitor with IC50 of 14 nM.
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DescriptionNVP-BVU972, also known as BVN-972, is a selective and potent inhibitor of c-Met with IC50 of 14 nM. BVN-972 displays IC50 values more than 1000 nM in other kinases such as the most closely related kinase recepteur d'origine nantais (RON).
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In VitroNVP-BVU972 (600 nM-9.6 μM; 72 h) shows good antiproliferative activity to BaF3 cells with MET mutations.NVP-BVU972 (0-10 μM; 2 h) reduces TPR-MET phosphorylation in a dose-dependent manner in BaF3 TPR-MET cells. Cell Proliferation Assay Cell Line:BaF3 TPR-MET cells Concentration:600 nM-9.6 μM Incubation Time:72 h Result:Exhibited good antiproliferative effect on BaF3 cells with MET mutations, showed IC50s of 1.2, 3.6, 14.1, 14.6, 31.5, >129 and >129 nM for M1211L, M1250T, F1200I, V1155L, L1195V, D1228A and Y1230H mutations, respectively.Showed antiproliferative effect on BaF3 cells containing wild-type (WT) TPR-MET, with an IC50 of 77 nM.Western Blot Analysis Cell Line:BaF3 TPR-MET cells Concentration:0, 0.01, 0.1, 1, 10 μM Incubation Time:2 h Result:Inhibited phosphorylation of TPR-MET in a dose-dependent manner.
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In Vivo——
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SynonymsNVP-BVU972 | NVP-BVU 972 | NVP-BVU-972
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PathwayCell Cycle/DNA Damage
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TargetPARP
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RecptorMet
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1185763-69-2
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Formula Weight340.38
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Molecular FormulaC20H16N6
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 42 mg/mL. 123.39 mM
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SMILESCn1cc(cn1)c1nn2c(Cc3cc4c(cc3)nccc4)cnc2cc1
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Chemical Name6-[[6-(1-methylpyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl]quinoline
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Tiedt R, et al. Y Res. 2011, 71(15), 5255-5264.
molnova catalog



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