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NU-6027
CAS No. 220036-08-8
NU-6027 ( NU6027;NU 6027 )
Catalog No. M13509 CAS No. 220036-08-8
NU-6027 (NU6027) is an ATP-competitive inhibitor of CDK1 and CDK2 with Ki of 2.5 uM and 1.3 uM respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 34 | Get Quote |
|
| 5MG | 55 | Get Quote |
|
| 10MG | 91 | Get Quote |
|
| 25MG | 186 | Get Quote |
|
| 50MG | 295 | Get Quote |
|
| 100MG | 441 | Get Quote |
|
| 500MG | 981 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameNU-6027
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NoteResearch use only, not for human use.
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Brief DescriptionNU-6027 (NU6027) is an ATP-competitive inhibitor of CDK1 and CDK2 with Ki of 2.5 uM and 1.3 uM respectively.
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DescriptionNU-6027 (NU6027) is an ATP-competitive inhibitor of CDK1 and CDK2 with Ki of 2.5 uM and 1.3 uM respectively; inhibits human tumor cells with a mean GI50 of 10 ±6 uM; also inhibits cellular ATR (IC50=6.7 uM) and RAD51 focus formation, increases the cytotoxicity of the major classes of DNA-damaging anticancer cytotoxic therapy.
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SynonymsNU6027;NU 6027
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PathwayAngiogenesis
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TargetCDK
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RecptorATR;CDK1;CDK2;DNA-PK
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number220036-08-8
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Formula Weight251.30
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Molecular FormulaC11H17N5O2
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Purity>98% (HPLC)
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SolubilityDMSO: 47 mg/mL (187 mM); Ethanol: 3 mg/mL (11.93 mM); Water: <1 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESNC1=NC(OCC2CCCCC2)=C(N=O)C(N)=N1
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Chemical Name6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diamine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Arris CE, et al. J Med Chem. 2000 Jul 27;43(15):2797-804.
2. Peasland A, et al. Br J Cancer. 2011 Jul 26;105(3):372-81.
3. Boschi D, et al. Eur J Med Chem. 2013 Oct;68:333-8.
2. Peasland A, et al. Br J Cancer. 2011 Jul 26;105(3):372-81.
3. Boschi D, et al. Eur J Med Chem. 2013 Oct;68:333-8.
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