HQ461

CAS No. 1226443-41-9

HQ461 ( —— )

Catalog No. M28932 CAS No. 1226443-41-9

HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 49 Get Quote
5MG 80 Get Quote
10MG 140 Get Quote
25MG 320 Get Quote
50MG 537 Get Quote
100MG 767 Get Quote
500MG 1557 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    HQ461
  • Note
    Research use only, not for human use.
  • Brief Description
    HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death.
  • Description
    HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death.
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    Apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1226443-41-9
  • Formula Weight
    345.4
  • Molecular Formula
    C15H15N5OS2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cc1cnc(NC(=O)Cc2csc(Nc3cccc(C)n3)n2)s1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Dabir DV, et, al. A small molecule inhibitor of redox-regulated protein translocation into mitochondria. Dev Cell. 2013 Apr 15;25(1):81-92.
molnova catalog
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