SJB3-019A

Research use only, not for human use.

A novel potent ubiquitin-specific protease USP1 inhibitor with IC50 of 78.1 nM.

A novel potent ubiquitin-specific protease USP1 inhibitor with IC50 of 78.1 nM, 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells; also increases the levels of Ub-FANCD2 and Ub-PCNA, and decreases the HR activity; triggers apoptosis in multiple myeloma cells via activation of caspase-3/8/9, degrades USP1 and downstream inhibitor of DNA-binding proteins as well as inhibits DNA repair via blockade of Fanconi anemia pathway and homologous recombination; downregulates multiple myeloma stem cell Notch-1, Notch-2, SOX-4, and SOX-2, and induces generation of more mature and differentiated plasma cells.

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Proteasome/Ubiquitin

DUB

DUB

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--

276.25

C16H8N2O3

>98% (HPLC)

10 mM in DMSO

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2-(pyridin-3-yl)naphtho[2,3-d]oxazole-4,9-dione

(-20℃)

With Ice Pack

≥ 2 years