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NSC49652

CAS No. 908563-68-8

NSC49652( —— )

Catalog No. M34352 CAS No. 908563-68-8

NSC49652 triggers apoptotic cell death dependent on p75NTR and JNK activity in neurons and melanoma cells, and inhibits tumor growth in a melanoma mouse model.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 47 Get Quote
5MG 68 Get Quote
10MG 116 Get Quote
25MG 227 Get Quote
50MG 361 Get Quote
100MG 530 Get Quote
500MG 1152 Get Quote
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Biological Information

  • Product Name
    NSC49652
  • Note
    Research use only, not for human use.
  • Brief Description
    NSC49652 triggers apoptotic cell death dependent on p75NTR and JNK activity in neurons and melanoma cells, and inhibits tumor growth in a melanoma mouse model.
  • Description
    NSC49652 is a reversible, orally active p75 neurotrophin receptor (p75NTR, also known as NGFR, TNFRSF16, and CD271) agonist. NSC49652 targets the transmembrane domain of p75NTR. NSC49652 induces apoptosis and affects the viability of melanoma cells.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    908563-68-8
  • Formula Weight
    225.24
  • Molecular Formula
    C14H11NO2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : ≥ 20.83 mg/mL (92.48 mM; )
  • SMILES
    Oc1ccccc1C(=O)\C=C\c1cccnc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Goh ETH, et al. A Small Molecule Targeting the Transmembrane Domain of Death Receptor p75NTR Induces Melanoma Cell Death and Reduces Tumor Growth. Cell Chem Biol. 2018 Dec 20;25(12):1485-1494.e5.?
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