Ginsenoside Rg6( —— )

Catalog No. M29052 CAS No. 147419-93-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Ginsenoside Rg6
Note

Research use only, not for human use.
Brief Description

Ginsenoside Rg6 inhibits the proliferation and induces apoptosis of human lymphoma JK cells
Description

Ginsenoside Rg6 inhibits the proliferation and induces apoptosis of human lymphoma JK cells(In Vitro):Ginsenoside Rg6 may inhibit the proliferation and induce apoptosis of human lymphoma JK cells through mitochondrial dysfunction and increased Bax expression and decreased Bcl-2 expression. In addition, ginsenoside Rg6 can also inhibit the transcriptional activity of NF-κB induced by TNF-α in SK-Hep1 cells with IC50 of 25uM.
In Vitro

Ginsenoside Rg6 inhibits TNF-α-induced NF-κB transcriptional activity with an IC50 of 25.12±1.04 μM in SK-Hep1 cells, consistent with the data from HepG2 cells. Ginsenoside Rg6 exhibits obvious anti-proliferative and apoptosis-inducing effects when it is applied to JK cells in vitro. Ginsenoside Rg6 blocks S arrest in the cell cycle. CCK-8 method shows that after Ginsenoside Rg6 is used, several groups with different concentrations obviously inhibits JK cell proliferation in human lymphocytoma, with evident dose dependency. Based on IC50, the median inhibitory concentration of Ginsenoside Rg6 is 83.08 μM.
In Vivo

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Synonyms

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Pathway

Apoptosis
Target

Apoptosis
Recptor

Apoptosis
Research Area

——
Indication

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CAS Number

147419-93-0
Formula Weight

767.01
Molecular Formula

C42H70O12
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (130.38 mM)
SMILES

[H][C@@]12[C@H](CC[C@@]1(C)[C@]1(C)C[C@@H](O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)C3C(C)(C)[C@H](O)CC[C@]3(C)[C@@]1([H])C[C@@H]2O)C(=C)CCC=C(C)C
Chemical Name

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