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NS13001

CAS No. 1063331-94-1

NS13001( N-(4-chlorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-9-methylpurin-6-amine | N-(4-Chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-9-methyl-9H-purin-6-amine )

Catalog No. M23269 CAS No. 1063331-94-1

NS13001 is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium channels).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 125 In Stock
10MG 219 In Stock
25MG 357 In Stock
50MG 529 In Stock
100MG 767 In Stock
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Biological Information

  • Product Name
    NS13001
  • Note
    Research use only, not for human use.
  • Brief Description
    NS13001 is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium channels).
  • Description
    NS13001 is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium channels). The EC50s are 1.8 and 0.14 μM for SK2 and SK3, respectively. NS13001 holds promise as a potential therapeutic agent for treatment of spinocerebellar ataxia type 2 (SCA2) and possibly other cerebellar ataxias.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    N-(4-chlorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-9-methylpurin-6-amine | N-(4-Chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-9-methyl-9H-purin-6-amine
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    SK2|SK3
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1063331-94-1
  • Formula Weight
    353.81
  • Molecular Formula
    C17H16ClN7
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 90 mg/mL (254.37 mM; Need ultrasonic)
  • SMILES
    Cc1cc(C)nn1-c(nc1Nc(cc2)ccc2Cl)nc2c1ncn2C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Kasumu AW, et al. Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2. Chem Biol. 2012 Oct 26;19(10):1340-53.
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