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NS13001
CAS No. 1063331-94-1
NS13001 ( N-(4-chlorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-9-methylpurin-6-amine; N-(4-Chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-9-methyl-9H-purin-6-amine )
Catalog No. M23269 CAS No. 1063331-94-1
NS13001 is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium channels).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 125 | In Stock |
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| 10MG | 219 | In Stock |
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| 25MG | 357 | In Stock |
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| 50MG | 529 | In Stock |
|
| 100MG | 767 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameNS13001
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NoteResearch use only, not for human use.
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Brief DescriptionNS13001 is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium channels).
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DescriptionNS13001 is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium channels). The EC50s are 1.8 and 0.14 μM for SK2 and SK3, respectively. NS13001 holds promise as a potential therapeutic agent for treatment of spinocerebellar ataxia type 2 (SCA2) and possibly other cerebellar ataxias.
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SynonymsN-(4-chlorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-9-methylpurin-6-amine; N-(4-Chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-9-methyl-9H-purin-6-amine
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PathwayOthers
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TargetOther Targets
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RecptorSK2;SK3
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Research Area——
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Indication——
Chemical Information
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CAS Number1063331-94-1
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Formula Weight353.8
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Molecular FormulaC17H16ClN7
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Purity>98% (HPLC)
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SolubilityDMSO: 90 mg/mL (254.37 mM; Need ultrasonic)
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SMILESCc1cc(C)nn1-c(nc1Nc(cc2)ccc2Cl)nc2c1ncn2C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Kasumu AW, et al. Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2. Chem Biol. 2012 Oct 26;19(10):1340-53.
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