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GNF351

CAS No. 1227634-69-6

GNF351 ( —— )

Catalog No. M22680 CAS No. 1227634-69-6

GNF351 is a full antagonist of the aryl hydrocarbon receptor (AHR)with the capacity to inhibit both DRE-dependent and -independent activity.?GNF351 is minimal toxicity in mouse or human keratinocytes.?

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    GNF351
  • Note
    Research use only, not for human use.
  • Brief Description
    GNF351 is a full antagonist of the aryl hydrocarbon receptor (AHR)with the capacity to inhibit both DRE-dependent and -independent activity.?GNF351 is minimal toxicity in mouse or human keratinocytes.?
  • Description
    GNF351 is a full antagonist of the aryl hydrocarbon receptor (AHR)with the capacity to inhibit both DRE-dependent and -independent activity.?GNF351 is minimal toxicity in mouse or human keratinocytes.?GNF351 competes with a photoaffinity AHR ligand for binding to the AHR (IC50: 62 nM).?After treating proliferating monolayer cultures of human keratinocytes, GNF351 (500 nM, 48 hours) obviously decreases the percentage of Ki67-positive cells and cell number.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    aryl hydrocarbon receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1227634-69-6
  • Formula Weight
    411.5
  • Molecular Formula
    C24H25N7
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:124 mg/mL(301.34 mM)
  • SMILES
    CC(C)n1cnc2c(NCCc3c[nH]c4ccccc34)nc(nc12)-c1cncc(C)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. van den Bogaard EH，et al. Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation. J Invest Dermatol. 2015 May;135(5):1320-1328.
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