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GNF351
CAS No. 1227634-69-6
GNF351( —— )
Catalog No. M22680 CAS No. 1227634-69-6
GNF351 is a full antagonist of the aryl hydrocarbon receptor (AHR)with the capacity to inhibit both DRE-dependent and -independent activity.?GNF351 is minimal toxicity in mouse or human keratinocytes.?
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 77 | In Stock |
|
| 10MG | 132 | In Stock |
|
| 25MG | 267 | In Stock |
|
| 50MG | 492 | In Stock |
|
| 100MG | 662 | In Stock |
|
| 200MG | 896 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGNF351
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NoteResearch use only, not for human use.
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Brief DescriptionGNF351 is a full antagonist of the aryl hydrocarbon receptor (AHR)with the capacity to inhibit both DRE-dependent and -independent activity.?GNF351 is minimal toxicity in mouse or human keratinocytes.?
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DescriptionGNF351 is a full antagonist of the aryl hydrocarbon receptor (AHR)with the capacity to inhibit both DRE-dependent and -independent activity.?GNF351 is minimal toxicity in mouse or human keratinocytes.?GNF351 competes with a photoaffinity AHR ligand for binding to the AHR (IC50: 62 nM).?After treating proliferating monolayer cultures of human keratinocytes, GNF351 (500 nM, 48 hours) obviously decreases the percentage of Ki67-positive cells and cell number.
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In VitroCell Proliferation Assay Cell Line:Human primary keratinocytes Concentration:500 nM Incubation Time:48 hours Result:Showed a significant reduction in the percentage of Ki67-positive cells and cell number after treating proliferating monolayer cultures of human keratinocytes for 48 hours.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptoraryl hydrocarbon receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number1227634-69-6
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Formula Weight411.5
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Molecular FormulaC24H25N7
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Purity>98% (HPLC)
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SolubilityDMSO:124 mg/mL(301.34 mM)
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SMILESCC(C)n1cnc2c(NCCc3c[nH]c4ccccc34)nc(nc12)-c1cncc(C)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. van den Bogaard EH，et al. Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation. J Invest Dermatol. 2015 May;135(5):1320-1328.
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