NCH-51
CAS No. 848354-66-5
NCH-51 ( NCH51 )
Catalog No. M16160 CAS No. 848354-66-5
NCH-51 is the S-isobutyryl prodrug of NCH-31, which is a potent HDAC inhibitor with IC50 of 48 nM for HDAC1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 102 | Get Quote |
|
5MG | 215 | Get Quote |
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10MG | 313 | Get Quote |
|
25MG | 501 | Get Quote |
|
50MG | 705 | Get Quote |
|
100MG | 981 | Get Quote |
|
500MG | 2007 | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
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Product NameNCH-51
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NoteResearch use only, not for human use.
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Brief DescriptionNCH-51 is the S-isobutyryl prodrug of NCH-31, which is a potent HDAC inhibitor with IC50 of 48 nM for HDAC1.
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DescriptionNCH-51 is the S-isobutyryl prodrug of NCH-31, which is a potent HDAC inhibitor with IC50 of 48 nM for HDAC1, inhibits cell proliferation of NCI-H460 and MDA-MB-231 with IC50 of 2.1 and 4.4 uM; inhibits the cell growth of a variety of lymphoid malignant cells through apoptosis induction, more effectively than SAHA, upregulates p21 and downregulated anti-apoptotic molecules including survivin, bcl-w and c-FLIP; also induces expression of latent HIV-1 through the Sp1 sites with minimal cytotoxicit in latently infected-cells.
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SynonymsNCH51
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PathwayCell Cycle/DNA Damage
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TargetHDAC
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RecptorHDAC
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number848354-66-5
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Formula Weight390.56
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Molecular FormulaC20H26N2O2S2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCC(C)C(SCCCCCCC(NC1=NC(C2=CC=CC=C2)=CS1)=O)=O
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Chemical NamePropanethioic acid, 2-methyl-, S-[7-oxo-7-[(4-phenyl-2-thiazolyl)amino]heptyl] ester
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sanda T, et al. Leukemia. 2007 Nov;21(11):2344-53.
2. Suzuki T, et al. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1558-61.
3. Suzuki T, et al. J Med Chem. 2005 Feb 24;48(4):1019-32.
4. Victoriano AF, et al. FEBS Lett. 2011 Apr 6;585(7):1103-11.
2. Suzuki T, et al. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1558-61.
3. Suzuki T, et al. J Med Chem. 2005 Feb 24;48(4):1019-32.
4. Victoriano AF, et al. FEBS Lett. 2011 Apr 6;585(7):1103-11.
molnova catalog
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