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Home - Products - Cell Cycle/DNA Damage - HDAC - Mocetinostat

Mocetinostat

CAS No. 726169-73-9

Mocetinostat ( MGCD0103;MGCD 0103;MGCD-0103 )

Catalog No. M15781 CAS No. 726169-73-9

An isotype-selective small molecule HDAC inhibitor that selectively inhibits HDAC1 (IC50=0.15 uM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 47 In Stock
25MG 72 In Stock
50MG 90 In Stock
100MG 142 In Stock
200MG 185 In Stock
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Biological Information

  • Product Name
    Mocetinostat
  • Note
    Research use only, not for human use.
  • Brief Description
    An isotype-selective small molecule HDAC inhibitor that selectively inhibits HDAC1 (IC50=0.15 uM).
  • Description
    An isotype-selective small molecule HDAC inhibitor that selectively inhibits HDAC1 (IC50=0.15 uM); also inhibits HDAC2/3/11; no effect on HDAC4/5/6/7/8; induces hyperacetylation of histones and caused cell cycle blockade in various human cancer cell lines; inhibits growth of human tumor xenografts in nude mice; orally bioactive.Blood Cancer Phase 2 Clinical
  • Synonyms
    MGCD0103;MGCD 0103;MGCD-0103
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    HDAC
  • Recptor
    HDAC1;HDAC11;HDAC2;HDAC3;HDAC4
  • Research Area
    Cancer
  • Indication
    Blood cancer

Chemical Information

  • CAS Number
    726169-73-9
  • Formula Weight
    396.44
  • Molecular Formula
    C23H20N6O
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    NC1=CC=CC=C1NC(=O)C1=CC=C(CNC2=NC=CC(=N2)C2=CN=CC=C2)C=C1
  • Chemical Name
    Benzamide, N-(2-aminophenyl)-4-[[[4-(3-pyridinyl)-2-pyrimidinyl]amino]methyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Fournel M, et al. Mol Cancer Ther. 2008 Apr;7(4):759-68.
2. Zhou N, et al. J Med Chem. 2008 Jul 24;51(14):4072-5.
3. Raeppel S, et al. Bioorg Med Chem Lett. 2009 Feb 1;19(3):644-9.
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