Cart
sales@molnova.com
AES-350
CAS No. 847249-57-4
AES-350 ( —— )
Catalog No. M24840 CAS No. 847249-57-4
AES-350 is a potent and orally active HDAC6 inhibitor(IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 286 | In Stock |
|
| 10MG | 475 | In Stock |
|
| 25MG | 786 | In Stock |
|
| 50MG | 1062 | In Stock |
|
| 100MG | 1458 | In Stock |
|
| 500MG | 2907 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameAES-350
-
NoteResearch use only, not for human use.
-
Brief DescriptionAES-350 is a potent and orally active HDAC6 inhibitor(IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively).
-
DescriptionAES-350 is a potent and orally active HDAC6 inhibitor(IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively). It is also against HDAC-3, -8, and -11 in an enzymatic activity assay with IC50 values of 0.187 μM, 0.245 μM, and >1μM, respectively. AES-350 triggers apoptosis in AML cells through HDAC inhibition and can be used for acute myeloid leukemia (AML) research.
-
Synonyms——
-
PathwayCell Cycle/DNA Damage
-
TargetHDAC
-
RecptorHDAC11;HDAC3;HDAC6
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number847249-57-4
-
Formula Weight312.4
-
Molecular FormulaC18H20N2O3
-
Purity>98% (HPLC)
-
SolubilityDMSO:100 mg/mL (320.14 mM; Need ultrasonic)
-
SMILESCC(C)(C)C1=CC=C(C(NC2=CC=C(C(NO)=O)C=C2)=O)C=C1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Andrew E Shouksmith, et al. Class I/IIb-Selective HDAC Inhibitor Exhibits Oral Bioavailability and Therapeutic Efficacy in Acute Myeloid Leukemia.
molnova catalog
related products
-
Liquiritin apioside
Liquiritin Apioside is one of the main active components in Suan-Zao-Ren decoction as a treatment for insomnia.
-
4-(1H-Pyrazol-4-yl)-...
Detail unknown.
-
RGFP966
RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM in cell-free assay.
