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AES-350
CAS No. 847249-57-4
AES-350 ( —— )
Catalog No. M24840 CAS No. 847249-57-4
AES-350 is a potent and orally active HDAC6 inhibitor(IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 286 | In Stock |
|
| 10MG | 475 | In Stock |
|
| 25MG | 786 | In Stock |
|
| 50MG | 1062 | In Stock |
|
| 100MG | 1458 | In Stock |
|
| 500MG | 2907 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAES-350
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NoteResearch use only, not for human use.
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Brief DescriptionAES-350 is a potent and orally active HDAC6 inhibitor(IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively).
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DescriptionAES-350 is a potent and orally active HDAC6 inhibitor(IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively). It is also against HDAC-3, -8, and -11 in an enzymatic activity assay with IC50 values of 0.187 μM, 0.245 μM, and >1μM, respectively. AES-350 triggers apoptosis in AML cells through HDAC inhibition and can be used for acute myeloid leukemia (AML) research.
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetHDAC
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RecptorHDAC11;HDAC3;HDAC6
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Research Area——
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Indication——
Chemical Information
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CAS Number847249-57-4
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Formula Weight312.4
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Molecular FormulaC18H20N2O3
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Purity>98% (HPLC)
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SolubilityDMSO:100 mg/mL (320.14 mM; Need ultrasonic)
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SMILESCC(C)(C)C1=CC=C(C(NC2=CC=C(C(NO)=O)C=C2)=O)C=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Andrew E Shouksmith, et al. Class I/IIb-Selective HDAC Inhibitor Exhibits Oral Bioavailability and Therapeutic Efficacy in Acute Myeloid Leukemia.
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