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NBD-557
CAS No. 333352-59-3
NBD-557 ( NBD 557;NBD557 )
Catalog No. M14122 CAS No. 333352-59-3
A potent HIV-1 entry inhibitor that blocks the gp120-CD4 interaction; inhibits the fusion between HIV-1NL4-3-luc pseudotyped virus expressing HIV-1HXB2 (X4-tropic) envelope and U87-T4-CXCR4 cells with IC50 of 9.7 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 110 | In Stock |
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| 5MG | 177 | In Stock |
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| 10MG | 327 | In Stock |
|
| 25MG | 554 | In Stock |
|
| 50MG | 789 | In Stock |
|
| 100MG | 1062 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNBD-557
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NoteResearch use only, not for human use.
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Brief DescriptionA potent HIV-1 entry inhibitor that blocks the gp120-CD4 interaction; inhibits the fusion between HIV-1NL4-3-luc pseudotyped virus expressing HIV-1HXB2 (X4-tropic) envelope and U87-T4-CXCR4 cells with IC50 of 9.7 uM.
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DescriptionA potent HIV-1 entry inhibitor that blocks the gp120-CD4 interaction; inhibits the fusion between HIV-1NL4-3-luc pseudotyped virus expressing HIV-1HXB2 (X4-tropic) envelope and U87-T4-CXCR4 cells with IC50 of 9.7 uM; inhibits the laboratory-adapted HIV-1 strains IIIB, MN, and V32 with IC50 of 5-16 uM.HIV Infection Preclinical
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SynonymsNBD 557;NBD557
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PathwayMicrobiology/Virology
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TargetHIV
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RecptorHIV
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Research AreaInfection
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IndicationHIV Infection
Chemical Information
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CAS Number333352-59-3
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Formula Weight382.30
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Molecular FormulaC17H24BrN3O2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(NC1=CC=C(Br)C=C1)C(NC2CC(C)(C)NC(C)(C)C2)=O
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Chemical NameEthanediamide, N-(4-bromophenyl)-N'-(2,2,6,6-tetramethyl-4-piperidinyl)- (9CI)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zhao Q, et al. Virology. 2005 Sep 1;339(2):213-25.
2. Schn A, et al. Biochemistry. 2006 Sep 12;45(36):10973-80.
3. Curreli F, et al. Antimicrob Agents Chemother. 2014 Sep;58(9):5478-91.
2. Schn A, et al. Biochemistry. 2006 Sep 12;45(36):10973-80.
3. Curreli F, et al. Antimicrob Agents Chemother. 2014 Sep;58(9):5478-91.
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