
MK-8591
CAS No. 865363-93-5
MK-8591( Islatravir | MK8591 | EFdA )
Catalog No. M16284 CAS No. 865363-93-5
MK-8591 (Islatravir, MK8591, EFdA) is a nucleoside analog that exhibits remarkable potency against wild-type and drug-resistant HIVs.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 312 | Get Quote |
![]() ![]() |
10MG | 507 | Get Quote |
![]() ![]() |
25MG | 801 | Get Quote |
![]() ![]() |
50MG | 1107 | Get Quote |
![]() ![]() |
100MG | 1503 | Get Quote |
![]() ![]() |
200MG | Get Quote | Get Quote |
![]() ![]() |
500MG | Get Quote | Get Quote |
![]() ![]() |
1G | Get Quote | Get Quote |
![]() ![]() |
Biological Information
-
Product NameMK-8591
-
NoteResearch use only, not for human use.
-
Brief DescriptionMK-8591 (Islatravir, MK8591, EFdA) is a nucleoside analog that exhibits remarkable potency against wild-type and drug-resistant HIVs.
-
DescriptionMK-8591 (Islatravir, MK8591, EFdA) is a nucleoside analog that exhibits remarkable potency against wild-type and drug-resistant HIVs, inhibits HIV-1 reverse transcriptase with multiple mechanisms; also retains potent activity against multinucleoside-resistant HIV-2 mutants (EC50<11 nM).HIV Infection Phase 2 Clinical.
-
In VitroIslatravir (MK-8591) (4'Ed2FA) is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC50s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively.
-
In Vivo——
-
SynonymsIslatravir | MK8591 | EFdA
-
PathwayMicrobiology/Virology
-
TargetHIV
-
RecptorHIV
-
Research AreaInfection
-
IndicationHIV Infection
Chemical Information
-
CAS Number865363-93-5
-
Formula Weight293.25
-
Molecular FormulaC12H12FN5O3
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (341.01 mM)
-
SMILESNC1=C(N=CN2[C@H]3C[C@@H]([C@@](O3)(C#C)CO)O)C2=NC(F)=N1
-
Chemical Name(2R,3S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-2-ethynyl-2-(hydroxymethyl)tetrahydrofuran-3-ol
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Wu VH, et al. Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00744-17.
2. Salie ZL, et al. Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):9274-9.
3. Michailidis E, et al. J Biol Chem. 2014 Aug 29;289(35):24533-48.
molnova catalog



related products
-
RN-18
RN-18 is a small molecule that antagonizes HIV-1 Vif function and inhibits HIV-1 replication only in the presence of A3G.
-
HAR-171
HAR-171 is a small molecule gp120-CD40 blocker that acts as a highly potent HIV entry inhibitor with IC50 of 0.43 uM against YTA48P virus.
-
MIV 150
A high-affinity, allosteric HIV-1 and HIV-2 reverse transcriptase inhibitor (NNRTI) with EC50 of 1 nM.