NBD-556

CAS No. 333353-44-9

NBD-556( NBD 556 | NBD556 )

Catalog No. M14123 CAS No. 333353-44-9

A potent HIV-1 entry inhibitor that blocks the gp120-CD4 interaction.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 31 Get Quote
5MG 50 Get Quote
10MG 87 Get Quote
25MG 146 Get Quote
50MG 214 Get Quote
100MG 322 Get Quote
200MG 475 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    NBD-556
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent HIV-1 entry inhibitor that blocks the gp120-CD4 interaction.
  • Description
    A potent HIV-1 entry inhibitor that blocks the gp120-CD4 interaction; inhibits the fusion between HIV-1NL4-3-luc pseudotyped virus expressing HIV-1HXB2 (X4-tropic) envelope and U87-T4-CXCR4 cells with IC50 of 20 uM; inhibits the laboratory-adapted HIV-1 strains IIIB, MN, and V32 with IC50 of 5-16 uM.HIV Infection Preclinical.
  • In Vitro
    NBD-556 (1-100 μM) inhibits HIV-1 envelope-mediated virus-cell and cell-cell fusion.NBD-556 inhibits the infection of MT-2 cells by laboratory-adapted HIV-1 IIIB, MN, and V32 strains, with IC50s of 6.5, 15.9, and 5.3 μM, respectively.NBD-556 (1-100 μM) inhibits the CD4-dependent virus in a dose-dependent manner with an IC50 of 22.6 μM.
  • In Vivo
    ——
  • Synonyms
    NBD 556 | NBD556
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    HIV
  • Research Area
    Infection
  • Indication
    HIV Infection

Chemical Information

  • CAS Number
    333353-44-9
  • Formula Weight
    337.8444
  • Molecular Formula
    C17H24ClN3O2
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(NC1CC(C)(C)NC(C)(C)C1)C(NC2=CC=C(Cl)C=C2)=O
  • Chemical Name
    Ethanediamide, N1-(4-chlorophenyl)-N2-(2,2,6,6-tetramethyl-4-piperidinyl)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zhao Q, et al. Virology. 2005 Sep 1;339(2):213-25. 2. Sch?n A, et al. Biochemistry. 2006 Sep 12;45(36):10973-80. 3. Curreli F, et al. Antimicrob Agents Chemother. 2014 Sep;58(9):5478-91.
molnova catalog
related products
  • NSC-34931

    A anti-HIV-1 compound that interferes with HIV-I integrase binding to viral DNA.

  • GS-9695

    GS-9695 is a potent, non-catalytic site HIV integrase inhibitor with wild type EC50 of 1.2 nM.

  • AST 487

    AST 487 is a RET kinase inhibitor, inhibiting RET autophosphorylation and activation of downstream effectors. It also can inhibit Flt-3.