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NBD-556

CAS No. 333353-44-9

NBD-556( NBD 556 | NBD556 )

Catalog No. M14123 CAS No. 333353-44-9

A potent HIV-1 entry inhibitor that blocks the gp120-CD4 interaction.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    NBD-556
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent HIV-1 entry inhibitor that blocks the gp120-CD4 interaction.
  • Description
    A potent HIV-1 entry inhibitor that blocks the gp120-CD4 interaction; inhibits the fusion between HIV-1NL4-3-luc pseudotyped virus expressing HIV-1HXB2 (X4-tropic) envelope and U87-T4-CXCR4 cells with IC50 of 20 uM; inhibits the laboratory-adapted HIV-1 strains IIIB, MN, and V32 with IC50 of 5-16 uM.HIV Infection Preclinical.
  • In Vitro
    NBD-556 (1-100 μM) inhibits HIV-1 envelope-mediated virus-cell and cell-cell fusion.NBD-556 inhibits the infection of MT-2 cells by laboratory-adapted HIV-1 IIIB, MN, and V32 strains, with IC50s of 6.5, 15.9, and 5.3 μM, respectively.NBD-556 (1-100 μM) inhibits the CD4-dependent virus in a dose-dependent manner with an IC50 of 22.6 μM.
  • In Vivo
    ——
  • Synonyms
    NBD 556 | NBD556
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    HIV
  • Research Area
    Infection
  • Indication
    HIV Infection

Chemical Information

  • CAS Number
    333353-44-9
  • Formula Weight
    337.8444
  • Molecular Formula
    C17H24ClN3O2
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(NC1CC(C)(C)NC(C)(C)C1)C(NC2=CC=C(Cl)C=C2)=O
  • Chemical Name
    Ethanediamide, N1-(4-chlorophenyl)-N2-(2,2,6,6-tetramethyl-4-piperidinyl)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zhao Q, et al. Virology. 2005 Sep 1;339(2):213-25. 2. Sch?n A, et al. Biochemistry. 2006 Sep 12;45(36):10973-80. 3. Curreli F, et al. Antimicrob Agents Chemother. 2014 Sep;58(9):5478-91.
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