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NBD-11021

CAS No. 1427304-84-4

NBD-11021( NBD11021 )

Catalog No. M11804 CAS No. 1427304-84-4

A small molecule, full antagonist of CD4 that blocks gp120-CD4 interaction.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    NBD-11021
  • Note
    Research use only, not for human use.
  • Brief Description
    A small molecule, full antagonist of CD4 that blocks gp120-CD4 interaction.
  • Description
    A small molecule, full antagonist of CD4 that blocks gp120-CD4 interaction; inhibits the CD4-dependent virus in a dose-dependent manner with IC50 of 2.4 uM; also weakly shows HIV-1 RT inhibition with IC50 of 43.4 uM; exhibits pan-neutralization activity against a panel of 56 Env-pseudotyped HIV-1 representing diverse subtypes of clinical isolates (IC50 as low as 270 nM).HIV Preclinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    NBD11021
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    HIV
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1427304-84-4
  • Formula Weight
    444.978
  • Molecular Formula
    C22H25ClN4O2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    5-(4-chlorophenyl)-N-((5-(hydroxymethyl)-4-methylthiazol-2-yl)(piperidin-2-yl)methyl)-1H-pyrrole-2-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Curreli F, et al. J Med Chem. 2015 Sep 10;58(17):6909-6927.
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