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Mocravimod

CAS No. 509092-16-4

Mocravimod ( KRP-203;KRP203 )

Catalog No. M14745 CAS No. 509092-16-4

A synthetic immunosuppressant that functions as a S1P1 receptor agonist.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Mocravimod
  • Note
    Research use only, not for human use.
  • Brief Description
    A synthetic immunosuppressant that functions as a S1P1 receptor agonist.
  • Description
    A synthetic immunosuppressant that functions as a S1P1 receptor agonist; significantly inhibits infiltration of inflammatory cells, expression of endothelin-1 and TGF-beta1, and IgG deposition and eventually attenuates neointimal formation and myocardial fibrosis; prolongs graft survival and attenuates chronic rejection in rat skin and heart allografts.Other IndicationPhase 2 Clinical
  • Synonyms
    KRP-203;KRP203
  • Pathway
    GPCR/G Protein
  • Target
    Lysophospholipid Receptor
  • Recptor
    Lysophospholipid Receptor
  • Research Area
    Other Indications
  • Indication
    Other Disease

Chemical Information

  • CAS Number
    509092-16-4
  • Formula Weight
    443.99
  • Molecular Formula
    C24H26ClNO3S
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    OCC(CCC1=CC=C(SC2=CC=CC(OCC3=CC=CC=C3)=C2)C=C1Cl)(N)CO
  • Chemical Name
    2-Amino-2-(2-(2-chloro-4-(3-benzyloxyphenylthio)phenyl)ethyl)-1,3-propanediol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Shimizu H, et al. Circulation. 2005 Jan 18;111(2):222-9.
2. Takahashi M, et al. Transplant Proc. 2005 Jan-Feb;37(1):143-5.
3. Suzuki C, et al. J Heart Lung Transplant. 2006 Mar;25(3):302-9.
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