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Siponimod

CAS No. 1230487-00-9

Siponimod ( BAF-312 )

Catalog No. M10909 CAS No. 1230487-00-9

Siponimod (BAF312) is a potent, selective S1P1/S1P5 receptor modulator with EC50 of 0.39/0.0.98 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Siponimod
  • Note
    Research use only, not for human use.
  • Brief Description
    Siponimod (BAF312) is a potent, selective S1P1/S1P5 receptor modulator with EC50 of 0.39/0.0.98 nM.
  • Description
    Siponimod (BAF312) is a potent, selective S1P1/S1P5 receptor modulator with EC50 of 0.39/0.0.98 nM, >1,000-fold selectivity over S1P2/3/4; suppresses ongoing disease symptoms in rat EAE, concentration-dependently increases GIRK current amplitude in atrial myocytes with EC50 of 15.8 nM, reduces peripheral absolute lymphocyte counts in vivo, exhibits potential as a treatment for immune-mediated diseases.Multiple Sclerosis Phase 3 Clinical
  • Synonyms
    BAF-312
  • Pathway
    GPCR/G Protein
  • Target
    Lysophospholipid Receptor
  • Recptor
    S1P1;S1P2;S1P3;S1P4;S1P5
  • Research Area
    Inflammation/Immunology
  • Indication
    Multiple Sclerosis

Chemical Information

  • CAS Number
    1230487-00-9
  • Formula Weight
    516.60
  • Molecular Formula
    C29H35F3N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 30 mg/mL
  • SMILES
    CCC1=C(CN2CC(C(O)=O)C2)C=CC(/C(C)=N/OCC3=CC(C(F)(F)F)=C(C4CCCCC4)C=C3)=C1
  • Chemical Name
    3-Azetidinecarboxylic acid, 1-[[4-[(1E)-1-[[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]imino]ethyl]-2-ethylphenyl]methyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Pan S, et al. ACS Med Chem Lett. 2013 Jan 4;4(3):333-7.
2. Gergely P, et al. Br J Pharmacol. 2012 Nov;167(5):1035-47.
3. Fryer RM, et al. PLoS One. 2012;7(12):e52985.
4. Selmaj K, et al. Lancet Neurol. 2013 Aug;12(8):756-67.
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