ASP6432 ( ASP 6432;ASP-6432 )

Catalog No. M11161 CAS No. 1282549-08-9

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HNMR

HPLC

MSDS

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Product Name

ASP6432
Note

Research use only, not for human use.
Brief Description

ASP6432 (ASP-6432) is a potent and selective antagonist of LPA1 receptor, does-dependently inhibits LPA-stimulated increase in intracellular calcium ion with IC50 of 11 nM.
Description

ASP6432 (ASP-6432) is a potent and selective antagonist of LPA1 receptor, does-dependently inhibits LPA-stimulated increase in intracellular calcium ion with IC50 of 11 nM; also inhibits the LPA-induced [Ca2+]i increase in cells expressing rat LPA1 (IC50=30 nM), weakly inhibits LPA-induced [Ca2+]i increase in cells expressing human LPA4 (IC50=114 nM), and shows no activity on LAP2/3; inhibits LPA-induced urethra and prostate contractions in isolated rat tissue strips and anesthetized rats, decreases the urethral perfusion pressure (UPP) anesthetized rats.Other Indication Phase 1 Discontinued
Synonyms

ASP 6432;ASP-6432
Pathway

GPCR/G Protein
Target

Lysophospholipid Receptor
Recptor

Lysophospholipid Receptor
Research Area

Other Indications
Indication

Other Disease

CAS Number

1282549-08-9
Formula Weight

598.77
Molecular Formula

C26H31KN4O6S2
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(C1=CC(OC)=C(O)C(OC)=C1)N(CC2=[S]C=C(C(N(S(=O)(NCC)=O)[K])=O)[N]2)CCCC3=CC=CC=C3
Chemical Name

2-((3,5-dimethoxy-4-methyl-N-(3-phenylpropyl)benzamido)methyl)-N-(N-ethylsulfamoyl)thiazole-4-carboxamide, potassium salt

1. Sakamoto K, et al. J Pharmacol Exp Ther. 2018 Jun 8. pii: jpet.118.247908.

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