Tianeptinaline ( —— )

Catalog No. M17052 CAS No.

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Tianeptinaline
Note

Research use only, not for human use.
Brief Description

Tianeptinaline is a class I HDAC-selective, brain penetrant analogue of tianeptine with IC50 of 0.24, 0.12 and 0.155 uM for HDAC1, 2 and 3 respectively.
Description

Tianeptinaline is a class I HDAC-selective, brain penetrant analogue of tianeptine with IC50 of 0.24, 0.12 and 0.155 uM for HDAC1, 2 and 3 respectively, does not inhibit HDAC6; has EC50 of 3.98 and 0.67 uM in H3K9ac and H4K12ac assays, respectively; increases histone acetylation, and enhances CREB-mediated transcription and the expression of Arc (activity-regulated cytoskeleton-associated protein); enhances contextual fear conditioning, a behavioral test of hippocampal-dependent memory, after in vivo administration.
Synonyms

——
Pathway

Cell Cycle/DNA Damage
Target

HDAC
Recptor

HDAC
Research Area

——
Indication

——

CAS Number

--
Formula Weight

527.08
Molecular Formula

C27H31ClN4O3S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(NC1=CC=CC=C1N)CCCCCNC(C2=CC=C(Cl)C=C23)C4=CC=CC=C4N(C)S3(=O)=O
Chemical Name

N-(2-aminophenyl)-7-((3-chloro-6-methyl-5,5-dioxido-6,11-dihydrodibenzo[c,f][1,2]thiazepin-11-yl)amino)heptanamide

1. Zhao WN, et al. ACS Chem Neurosci. 2018 Jun 22. doi: 10.1021/acschemneuro.8b00116.

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