Tianeptinaline

Research use only, not for human use.

Tianeptinaline is a class I HDAC-selective, brain penetrant analogue of tianeptine with IC50 of 0.24, 0.12 and 0.155 uM for HDAC1, 2 and 3 respectively.

Tianeptinaline is a class I HDAC-selective, brain penetrant analogue of tianeptine with IC50 of 0.24, 0.12 and 0.155 uM for HDAC1, 2 and 3 respectively, does not inhibit HDAC6; has EC50 of 3.98 and 0.67 uM in H3K9ac and H4K12ac assays, respectively; increases histone acetylation, and enhances CREB-mediated transcription and the expression of Arc (activity-regulated cytoskeleton-associated protein); enhances contextual fear conditioning, a behavioral test of hippocampal-dependent memory, after in vivo administration.

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Cell Cycle/DNA Damage

HDAC

HDAC

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527.08

C27H31ClN4O3S

>98% (HPLC)

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O=C(NC1=CC=CC=C1N)CCCCCNC(C2=CC=C(Cl)C=C23)C4=CC=CC=C4N(C)S3(=O)=O

N-(2-aminophenyl)-7-((3-chloro-6-methyl-5,5-dioxido-6,11-dihydrodibenzo[c,f][1,2]thiazepin-11-yl)amino)heptanamide

(-20℃)

With Ice Pack

≥ 2 years