HDAC1,2-IN-2 ( MRLB223; MRLB 223; MRLB-223 )

Catalog No. M16716 CAS No. 937727-03-2

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HPLC

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Product Name

HDAC1,2-IN-2
Note

Research use only, not for human use.
Brief Description

A potent, selective HDAC1 and HDAC2 inhibitor with IC50 of 6 nM and 45 nM, respectively.
Description

A potent, selective HDAC1 and HDAC2 inhibitor with IC50 of 6 nM and 45 nM, respectively; displays highly selectivity over HDAC3 (IC50=7.0 μM), HDAC8 and 11 (IC50=20-25 uM) and no activity on HDACs 4-7; increases lysine 5 of histone H2B (H2BK5) in HCT116 colon carcinoma cells with IC50 of 400 nM, inhibited the cell growth with GI50 of 97 nM; exhibits tumor growth inhibition in HCT116 xenograft mice.
Synonyms

MRLB223; MRLB 223; MRLB-223
Pathway

Cell Cycle/DNA Damage
Target

HDAC
Recptor

HDAC
Research Area

——
Indication

——

CAS Number

937727-03-2
Formula Weight

449.53
Molecular Formula

C23H23N5O3S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(NC1=CC(C2=CC=CS2)=CC=C1N)C3=CC=C(N=C3)N(CC4)CCC4(O5)CNC5=O
Chemical Name

N-(2-amino-5-(thiophen-2-yl)phenyl)-6-(2-oxo-1-oxa-3,8-diazaspiro[4.5]decan-8-yl)nicotinamide

1. Hamblett CL, et al. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5300-9.
2. Methot JL, et al. ACS Med Chem Lett. 2014 Jan 2;5(4):340-5.

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